ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Synonymes:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Espèce(s):
Human ABCB1 (5243), dog ABCB1 (403879), domestic cat ABCB1 (493707), Thale Cress ABCB1 (818265), naked mole-rat Abcb1 (101702843), domestic guinea pig Abcb1 (100733532), Domestic Rabbit ABCB1 (100008914), sheep ABCB1 (443367), Horse ABCB1 (100034074), cow ABCB1 (281585)
ID UniProtKB:
ID du gène:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Thale Cress(818265) ABC transporter B family member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
Référence du produit
Description
Espèce(s)
Hydrocortisone solution, 50 μM, sterile-filtered, BioXtra, suitable for cell culture,
Espèce(s)
human, mouse, rat
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture,
Espèce(s)
human, mouse, rat
Small Molecule - Antagonist
Référence du produit
Description
Espèce(s)
Antibodies
Référence du produit
Description
Espèces réactives
Application
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse, clone F4, ascites fluid,
Espèces réactives
hamster, human
Application
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
Anti-MDR-1 Antibody, clone 1O12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, mouse
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
Espèces réactives
hamster, human
Application
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57, clone MC57, Chemicon®, from mouse,
Espèces réactives
human
Application
flow cytometry
immunohistochemistry
immunohistochemistry
Cell Lines
Kits
Référence du produit
Description
Espèce(s)
Small Molecule - Mixed Agonist/Antagonist
Référence du produit
Description
Espèce(s)
Dexaméthasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Espèce(s)
mouse, rat, human
Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture,
Espèce(s)
mouse, human, rat
Proteins
Référence du produit
Description
Espèce(s)
SB-MDR1-Hi5-PREDEASY-ATPase kit, membrane based kit for Human MDR1 ATPase Transport Assays,
Espèce(s)
human
esiRNA
Référence du produit
Description
Espèce(s)