Corticotropin Releasing Factor Antagonist

Name: Corticotropin Releasing Factor Antagonist
Brand: SIGMA

≥97% (HPLC)

Synonym(s):

α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)

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About This Item

Empirical Formula (Hill Notation):

C₁₆₆H₂₇₄N₄₆O₅₃S₂

CAS Number:

99658-03-4

Molecular Weight:

3826.36

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD00081543

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Properties

Quality Segment

200

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

Gene Information

human ... CRH(1392)
mouse ... CRH(12918)
rat ... CRH(81648)

Description

Biochem/physiol Actions

Exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors.

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

Other Notes

Lyophilized from 0.1% TFA in H2O

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This Item	C2671	C3042	C0961
Sigma-Aldrich C2917 Corticotropin Releasing Factor Antagonist	Sigma-Aldrich C2671 Corticotropin Releasing Factor bovine	Sigma-Aldrich C3042 Corticotropin Releasing Factor human, rat	Sigma-Aldrich C0961 Corticotropin Releasing Factor Fragment 6-33 human, rat
assay ≥97% (HPLC)	assay ≥90% (HPLC)	assay ≥95% (HPLC)	assay ≥97% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
Gene Information human ... CRH(1392) mouse ... CRH(12918) rat ... CRH(81648)	Gene Information cow ... CRH(280755)	Gene Information human ... CRH(1392)	Gene Information human ... CRH(1392)