Tangential Flow Filtration Devices
From single-use to multi-use, our tangential flow filtration (TFF) products are ideal for pharma and biopharma manufacturing.
Section Overview
Pellicon® Single-Pass TFF
Single-pass TFF with our Pellicon® capsules and cassettes streamlines processing by concentrating process streams without the recirculation of traditional TFF. This is a simple way to increase capacity, concentration, and product recovery while improving footprint. This versatile application also enables continuous and intensified processing, in which in-line volume reduction is coupled to other process steps.
Pellicon® Capsules
Pellicon® Capsules with Ultracel® membrane combine streamlined ultrafiltration and diafiltration with ease of use and process flexibility. This innovative single-use TFF capsule delivers superior mass transfer, flux and optimum recovery in a unique plug-and-play, holderless device that comes gamma sterilized and ready to process in minutes.
Pellicon® 3 Cassettes
Pellicon® 3 cassettes deliver high protein yield and consistent performance while offering broad chemical compatibility. They are available with Ultracel® and Biomax® membranes for different processing needs, including mAbs, plasma, insulin, peptides, and vaccines. To overcome the filtration challenges of high viscosity, our Pellicon® 3 cassettes with D screen are easy to use, enable faster processing and are optimized to achieve higher protein concentrations.
Pellicon® 2 Cassettes
Pellicon® 2 cassettes are ideal for the ultrafiltration and diafiltration of biologics including concentration, desalting, and buffer exchange of polysaccharides, virus suspensions, and protein solutions. Our Ultracel® and Biomax® membranes offer efficient ultrafiltration while Durapore® membrane is best suited for microfiltration.
Pellicon® XL 50 Cassettes
Pellicon® XL 50 cassettes couple our ultrafiltration and microfiltration membranes with linear scalability for process development or small-volume processing.
Prostak™ Microfiltration Modules
Prostak™ microfiltration modules provide robust construction, reliable performance, and steam-in-place capability, making them suitable for clarification, cell harvest, and multi-use perfusion. The low hold-up volume and open channel design allow high product recovery and gentle flow path for processing shear-sensitive materials.
Support for Qualification, Risk Assessment, and Process Optimization
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Related Articles
- Tangential Flow Filtration in Downstream Bioprocessing
There are many options for tangential flow filtration (TFF) in downstream bioprocessing from multi-use to single-use TFF or batch TFF and single-pass TFF.
- Tangential Flow Filtration in the Antibody Drug Conjugate (ADC) Manufacturing Process
Find best practices for using Pellicon® Capsules in ADC processing as well as data from two studies using Pellicon® Capsules and Pellicon® cassettes in the ADC manufacturing process.
- Single-Pass Tangential Flow Filtration Implementation and Scaling
Get practical guidance on using single-pass tangential flow filtration in your downstream process and scaling between capsules and cassettes.
Related Product Resources
- Data Sheet: Pellicon® Capsules with Ultracel® Membrane
Accelerate your therapy using our innovative single-use tangential flow filters with superior flux performance
- Data Sheet: Pellicon® 3 Cassettes with Ultracel® Membrane
The optimum tangential flow filtration devices for monoclonal antibodies and other therapeutic proteins.
- Data Sheet: Pellicon® 3 Cassettes with Biomax® Membrane
The device of choice for applications requiring higher yield, fast processing, and exceptional chemical resistance
- Data Sheet: Pellicon® 2 Filters and Holders
High performance tangential flow filters for biopharmaceutical process development, scale-up and scale-down, concentration, purification, and cell harvesting applications.
- Data Sheet: Prostak™ Microfiltration Modules
Prostak™ modules are tangential flow stacked plate membrane devices with open feed channels, made for use in Prostak™ tangential flow filtration (TFF) systems.
- Data Sheet: Pellicon® XL 50 Cassettes
Easy-to-use, high performance, linearly scalable tangential flow filtration cassette for process development work at volumes from 50 to 1000 mL
- Data Sheet: Pellicon® Single-Pass Tangential Flow Filtration
Pellicon® single-pass tangential flow filtration (single-pass TFF) is a versatile technology for more productive, high capacity and cost effective downstream processes that allows facilities to meet the demands of higher titer and connected or continuous processes
- Data Sheet: Ultracel® Membranes
The membrane of choice for ultra-low protein binding and robust performance during concentration and diafiltration of therapeutics
- Data Sheet: Biomax® Membranes
The membrane of choice for fast processing and exceptional chemical resistance
- Performance Guide: Pellicon® Capsules with Ultracel® Membrane
Innovative, high performance single-use tangential flow filtration devices that offer ease-of-use, operational flexibility, and enhanced operator safety.
- Application Note: Pellicon® Capsules for Single-use Tangential Flow Filtration
The Pellicon® Capsule is the first of its kind—a true single-use TFF device that streamlines bioprocessing with its innovative, simplified design and user-friendly features.
- Performance Guide: Pellicon® 3 Cassettes with Ultracel® Membrane
The tangential flow filtration devices of choice for demanding filtration processes requiring unbeatable performance consistency.
- Performance Guide: Pellicon® 3 Cassettes with Biomax® Membrane
The tangential flow filtration device of choice for demanding filtration processes requiring unbeatable performance consistency
- Application Note: Pellicon® 3 Cassettes with High Viscosity Feed Screen
Pellicon® 3 Cassettes with Ultracel® and Biomax® 30kD Membrane utilizing D screen geometry are engineered to efficiently process higher viscosity products.
- Application Note: Process Optimization and Scalability Evaluation of Pellicon® Capsules for Single-pass Tangential Flow Filtration of mAb-Based Biomolecules
Single-pass tangential flow filtration (SPTFF) is a method of ultrafiltration for the purposes of either volume reduction or protein concentration.
- White Paper: Streamlining Bioprocessing Using Pellicon® Cassettes for Single-pass Operation
Single-pass TFF is an enhanced approach to the existing TFF technology that has been used for the purification of monoclonal antibodies, therapeutic proteins, and vaccines at different steps within downstream processing
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