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Über diesen Artikel
material
clear polystyrene , clear wells
sterility
sterile
feature
lid
packaging
pkg of 5 ea
manufacturer/tradename
Advanced Pharmaceutical Sciences 71034
technique(s)
cell culture: suitable
size
24 wells
working volume
300 μL
color
clear
suitability
suitable for (suitable for multiple organ co-culture)
binding type
Collagen I coated surface
General description
In previous in vitro systems, each cell type was studied in isolation, ignoring critical interactions between organs when metabolizing drugs. This led to the possibility of many factors such as inter-organ toxicity going unrecognized in drug evaluations. The IdMOC models in vivo multiple-organ interaction, thus allowing the evaluation of organ-specific effects of a drug and its metabolites. The IdMOC consists of multiple, inner wells within a larger interconnecting chamber. Multiple cell types are first individually cultured in the inner wells in media optimized for each cell type.
On the day of experimentation, the individual media are removed and the chamber is filled with a single universal medium, flooding the inner wells and allowing well-to-well communication via the overlying medium. The test material is then added to the overlying medium. After experimentation, the overlying medium can be analyzed for overall metabolism of the test material, and individual cell types can be processed for the quantification of associated test material to evaluate possible organ-specific bioaccumulation, evaluation of cell viability for cytotoxicity, and efficacy.
Applications:
- Efficacy: Evaluation of the desired on-target and off-target effects via the examination of pharmacological effects of a drug in cells from target organs as well as off-target organs
- Drug distribution: Estimation of the potential differential drug distribution in multiple organs via the quantification of drugs in cells from multiple organs after exposure
- Drug metabolism: Drug stability and metabolite formation after metabolism by cells from multiple organs
- Drug toxicity: Simultaneous evaluation of toxic potential of a drug on cells from multiple organs under identical experimental conditions
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Dieser Artikel | |||
|---|---|---|---|
| description 4 chambers, size 24 wells, pkg of 5 ea | description coated, size 24 wells | description size 24 wells, flat bottom wells, case of 100 (20 Bulk Packs of 5), sterile, lid | description size 48 wells, flat clear bottom, sterile, lid |
| binding type Collagen I coated surface | binding type Collagen I coated surface | binding type Tissue Culture (TC)-treated surface | binding type CellBIND® surface |
| manufacturer/tradename Advanced Pharmaceutical Sciences 71034 | manufacturer/tradename Advanced Pharmaceutical Sciences 71010 | manufacturer/tradename Corning 3527 | manufacturer/tradename Corning 3338 |
| sterility sterile | sterility sterile | sterility sterile | sterility sterile |
| feature lid | feature lid | feature skirt, lid | feature skirt, lid |
| material clear polystyrene , clear wells | material polystyrene , colorless wells | material flat bottom wells, polystyrene plate, clear bottom, round clear wells | material flat bottom wells clear , clear polystyrene plate, flat clear bottom |
| suitability suitable for (suitable for multiple organ co-culture) | suitability suitable for (multiple organ co-culture) | suitability - | suitability suitable for (cell culture involving anchorage-dependant cell lines) |
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Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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