UC429

Midazolam -hydrochlorid

solid

• Synonym(e): 8-Chlor-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepin -hydrochlorid
• Empirische Formel (Hill-System): C₁₈H₁₃ClFN₃ · HCl
• CAS-Nummer: 59467-96-8
• Molekulargewicht: 362.23
• UNSPSC Code: 12161501
• PubChem Substance ID: 24724654
• EC Number: 261-776-6
• MDL number: MFCD00864445

Eigenschaften

• InChI key: DDLIGBOFAVUZHB-UHFFFAOYSA-N
• InChI: 1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
• SMILES string: Cc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12
• form: solid
• Gene Information: human ... ABCB1(5243), CYP3A4(1576), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879) ; mouse ... Abcb1a(18671), Abcb1b(18669) ; rat ... Gabbr1(81657), Gabra1(29705)
• drug control: USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland
• color: white to off-white
• solubility: H₂O: soluble at least 1 mg/mL
• storage temp.: 2-8°C

Beschreibung

Application

Midazolam has been used as an anesthetic for surgical experiments in rats[1]. This anesthetic has also been used in rats to study the interactions between midazolam and bupivacaine[2].

Biochem/physiol Actions

Sedative/hypnotic; ligand for the GABA_A receptor benzodiazepine modulatory site; CYP3A4 substrate.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Midazolam hydrochloride is soluble in water to at least 1 mg/ml. Product solutions should be protected from light.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)