U6508

UCN-01

≥97% (HPLC), PKC inhibitor, powder

• Synonym(e): KW-2401
• Empirische Formel (Hill-System): C₂₈H₂₆N₄O₄
• CAS-Nummer: 112953-11-4
• Molekulargewicht: 482.53
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724639
• NACRES: NA.77
• MDL number: MFCD26960886
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: protect from light

Eigenschaften

• Produktname: UCN-01, ≥97% (HPLC), powder
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]20/D 130 to 160°, c = 0.2 in DMSO
• storage condition: protect from light
• color: light yellow
• solubility: DMSO: >5 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: [H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8
• InChI: 1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
• InChI key: PBCZSGKMGDDXIJ-HQCWYSJUSA-N
• Gene Information: human ... CDK2(1017), CDK4(1019), CDK6(1021), CHEK1(1111), PDPK1(5170), PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584), PRKCQ(5588), PRKCZ(5590), PRKD1(5587), PRKD3(23683)

Beschreibung

Application

UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.

Biochem/physiol Actions

UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.

Features and Benefits

This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable