T8543

O-Tricyclo[5.2.1.0^2,6]dec-9-yl dithiocarbonate potassium salt

synthetic (organic), ≥95%,  phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor, solid

• Synonym(e): D609
• Empirische Formel (Hill-System): C₁₁H₁₅KOS₂
• CAS-Nummer: 83373-60-8
• Molekulargewicht: 266.46
• NACRES: NA.77
• PubChem Substance ID: 24278031
• UNSPSC Code: 41106300
• EC Number: 280-379-9
• MDL number: MFCD00171401
• Assay: ≥95%
• Form: solid

Eigenschaften

• Produktname: O-Tricyclo[5.2.1.0^2,6]dec-9-yl dithiocarbonate potassium salt, ≥95%, solid
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥95%
• form: solid
• color: off-white to yellow
• solubility: H₂O: soluble 50 mg/mL, clear to slightly hazy, colorless to faintly yellow, acetone: easily soluble, diethyl ether: insoluble, hydrocarbons: insoluble
• SMILES string: [K]SC(=S)OC1CC2CC1C3CCCC23
• InChI: 1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);/q;+1/p-1/t6-,7?,8?,9-,10?;/m1./s1
• InChI key: IGULCCCBGBDZKQ-HJPGVBIPSA-M

Beschreibung

Application

D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E^-/- mice.

Biochem/physiol Actions

D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids.

Phosphatidylcholine-specific phospholipase C (PLC) and HIV-1 inhibitor. Xanthogenate derivative with in vitro anti-tumor activity.

Preparation Note

O-Tricyclo[5.2.1.0^2,6]dec-9-yl dithiocarbonate or D609 is soluble in water at 50 mg/ml and yields a clear to slightly hazy, colorless to light yellow solution. It is also soluble in acetone. However, it is insoluble in ether and hydrocarbons.

Alcoholic solutions should not be prepared due to the possibility of transesterification. The product is very labile in solution (1.5 days half-life in tissue culture medium) and is readily hydrolyzed below pH 6.0. Hence, solutions should be prepared immediately before use and unused solutions must be discarded. For tissue culture preparations, the media should be buffered to pH 6.0-7.5. HEPES buffer must not be used as it renders this product toxic.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)