T0557

Natriumtaurodesoxycholat Hydrat

BioXtra, ≥97% (TLC)

• Synonym(e): 2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]-amino)-ethansulfonsäure, Taurodeoxycholsäure Natriumsalz Hydrat
• Lineare Formel: C₂₆H₄₄NO₆SNa · xH₂O
• CAS-Nummer: 207737-97-1
• Molekulargewicht: 521.69 (anhydrous basis)
• UNSPSC Code: 12161900
• NACRES: NA.25
• PubChem Substance ID: 24899897
• MDL number: MFCD00149238
• Beilstein/REAXYS Number: 3901204

Eigenschaften

• description: anionic
• Quality Segment: 200
• product line: BioXtra
• assay: ≥97% (TLC)
• mol wt: micellar avg mol wt 3100
• aggregation number: 6
• impurities: ≤0.002% Phosphorus (P), ≤0.1% Insoluble matter
• CMC: 1-4 mM (20-25°C)
• solubility: H₂O: 0.5 M, clear, colorless to faintly yellow
• anion traces: chloride (Cl^-): ≤0.5%, sulfate (SO₄^2-): ≤0.05%
• cation traces: Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.01%, Mg: ≤0.005%, NH₄⁺: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%
• SMILES string: O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
• InChI: 1S/C26H45NO6S.Na.H2O/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;;/m1../s1
• InChI key: OLPIZAYYAVQETM-GGPRKOIFSA-M

Beschreibung

General description

Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.

Application

Zu den Gallensalzen gehörendes anionisches Detergens, das zur Isolierung von Membranproteinen verwendet wird, einschließlich Proteinen der inneren mitochondrialen Membran.

Sodium tauroursodeoxycholate has been used in a study to assess short-term feedback regulation of bile salt uptake in rodent liver. It has also been used in a study to investigate its potential to resolve endoplasmic reticulum (ER) stress in intestinal epithelial cells. It is also used for isolation of membrane proteins including inner mitochondrial membrane proteins.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)