The molecular weight is 37 kilodaltons (kDa).
Fortfahren mit
SRP6556
Thrombin Active (High Activity) from bovine plasma
≥98% (SDS-PAGE), recombinant, lyophilized
Synonym(e):
Activated Factor IIa
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Über diesen Artikel
UNSPSC Code:
12352202
NACRES:
NA.32
Biological source:
bovine plasma
Assay:
≥98% (SDS-PAGE)
Form:
lyophilized
Mol wt:
37 kDa
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Technischer Dienst
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Unterstützung erhaltenProduktname
Thrombin Active (High Activity) from bovine plasma, ≥98% (SDS-PAGE)
biological source
bovine plasma
assay
≥98% (SDS-PAGE)
form
lyophilized
potency
>1500 units/mg
mol wt
37 kDa
packaging
pkg of 10,000 units, pkg of 100,000 units, pkg of 1000 units
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
bovine ... F2(280685)
General description
Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions.
Biochem/physiol Actions
Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity. Thrombin enzyme (Activated Factor IIa) also participates in inflammation and has mitogenic role on vascular cells. It is also involved in the activation of protein C which is needed for the inactivation of many procoagulant enzymes.
Physical form
Sterile filtered and lyophilized with Mannitol and Sodium Chloride.
Preparation Note
Reconstitute in sterile water (100 U/mL) with 0.9% NaCl. It forms a clear solution.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (SDS-PAGE) | description ≥95% (SDS-PAGE) | description lyophilized powder, 600-2,000 NIH units/mg protein (biuret) | description lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280 = 19.5) |
| assay ≥98% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay - | assay - |
| biological source bovine plasma | biological source human | biological source - | biological source - |
| form lyophilized | form lyophilized | form lyophilized powder | form lyophilized powder |
| mol wt 37 kDa | mol wt 37 kDa | mol wt heavy chain ~33 kDa, light chain ~5 kDa | mol wt light chain ~5 kDa, heavy chain ~33 kDa |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| shipped in wet ice | shipped in wet ice | shipped in - | shipped in - |
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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