SML2296

GSK180736A

≥98% (HPLC)

• Synonym(e): 4-(4-Fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide, GSK 180736A
• Empirische Formel (Hill-System): C₁₉H₁₆FN₅O₂
• CAS-Nummer: 817194-38-0
• Molekulargewicht: 365.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD30533616

Eigenschaften

• Produktname: GSK180736A, ≥98% (HPLC)
• InChI: 1S/C19H16FN5O2/c1-10-16(17(24-19(27)22-10)11-2-4-13(20)5-3-11)18(26)23-14-6-7-15-12(8-14)9-21-25-15/h2-9,17H,1H3,(H,21,25)(H,23,26)(H2,22,24,27)
• InChI key: HEAIGWIZTYAQTC-UHFFFAOYSA-N
• SMILES string: O=C(NC1=CC=C(NN=C2)C2=C1)C3=C(C)NC(NC3C4=CC=C(F)C=C4)=O
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

GSK180736A is a potent and selective dual inhibitor of a ROCK1 (Rho-associated, coiled-coil-containing protein kinase) and GRK2 (G protein-coupled receptor kinase 2). GSK180736A binds to the GRK2 active site. GSK180736A produces a significant cardiomyocytes contraction at 1 μM.

potent and selective dual inhibitor of a ROCK1 and GRK2

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable