SML2249

LSN3154567

≥98% (HPLC)

• Synonym(e): 2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide, Nampt-IN-1; 2-Hydoxy-2-methyl-N-{2-[(pyridin-3-yloxy)acetyl]-1,2,3,4-tetrahydroisoquinolin-6-YL}propane-1-sulfonamide
• Empirische Formel (Hill-System): C₂₀H₂₅N₃O₅S
• CAS-Nummer: 1698878-14-6
• Molekulargewicht: 419.49
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD28963946
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• SMILES string: [S](=O)(=O)(Nc1cc2c(cc1)CN(CC2)C(=O)COc3cnccc3)CC(O)(C)C
• InChI: 1S/C20H25N3O5S/c1-20(2,25)14-29(26,27)22-17-6-5-16-12-23(9-7-15(16)10-17)19(24)13-28-18-4-3-8-21-11-18/h3-6,8,10-11,22,25H,7,9,12-14H2,1-2H3
• InChI key: QHHSCLARESIWBH-UHFFFAOYSA-N
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

LSN3154567 is an orally available, potent and highly selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). LSN3154567 exhibits broad spectrum and potent anticancer activities without causing retinopathy in the rat. LSN3154567co-administration with nicotinic acid (NA) produces potent anti-tumor activity in tumor xenograft models without retinal and hematological toxicities.

LSN3154567 might be useful in developing a novel cancer therapeutic.[1]

orally available, potent and highly selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable