SML2063

Davunetide trifluoroacetate salt

≥95% (HPLC)

• Synonym(e): AL-108, Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln, L-Asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-Glutamine, NAP, NAP peptide, NAPVSIPQ
• Empirische Formel (Hill-System): C₃₆H₆₀N₁₀O₁₂ · xC₂HF₃O₂
• CAS-Nummer: 211439-12-2
• Molekulargewicht: 824.92 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥95% (HPLC)
• form: powder
• composition: Peptide content, ≥60%
• color: white to beige
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: N2([C@@H](CCC2)C(=O)N[C@@H](CCC(=O)N)C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)N)C)C(C)C)CO)[C@H](CC)C
• InChI: 1S/C36H60N10O12/c1-6-18(4)28(35(56)46-14-8-9-23(46)31(52)41-21(36(57)58)11-12-25(38)48)44-30(51)22(16-47)42-33(54)27(17(2)3)43-32(53)24-10-7-13-45(24)34(55)19(5)40-29(50)20(37)15-26(39)49/h17-24,27-28,47H,6-16,37H2,1-5H3,(H2,38,48)(H2,39,49)(H,40,50)(H,41,52)(H,42,54)(H,43,53)(H,44,51)(H,57,58)/t18-,19-,20-,21-,22-,23-,24-,27-,28-/m0/s1
• InChI key: DWLTUUXCVGVRAV-XWRHUKJGSA-N

Beschreibung

Biochem/physiol Actions

Davunetide (NAPVSIPQ; NAP) is an eight amino acid peptide identified as the active component of activity-dependent neuroprotective protein (ADNP). It has been found to be neuro-protective at femtomolar concentrations in vitro against the neural toxicity of a wide range of compounds. Davunetide has been investigated for Parkinson′s disease and schizophrenia and in clinical trials for Alzheimner′s Disease, targeting microtubule-tau Interaction.

Neuroprotective peptide; the neuronal tubulin-preferring agent

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable