SML1226

YM-26734

≥95% (HPLC)

• Synonym(e): 1,1′-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis1-dodecanone
• Empirische Formel (Hill-System): C₄₅H₆₂O₈
• CAS-Nummer: 144337-18-8
• Molekulargewicht: 730.97
• NACRES: NA.77
• PubChem Substance ID: 329825731
• UNSPSC Code: 41106300
• MDL number: MFCD00918068
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OC1=C(C2CC(C3=CC=C(O)C=C3)OC4=C2C=CC(O)=C4)C(O)=C(C(CCCCCCCCCCC)=O)C(O)=C1C(CCCCCCCCCCC)=O
• InChI: 1S/C45H62O8/c1-3-5-7-9-11-13-15-17-19-21-36(48)41-43(50)40(44(51)42(45(41)52)37(49)22-20-18-16-14-12-10-8-6-4-2)35-30-38(31-23-25-32(46)26-24-31)53-39-29-33(47)27-28-34(35)39/h23-29,35,38,46-47,50-52H,3-22,30H2,1-2H3
• InChI key: CEJAYJCUSZHYDS-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

YM-26734 is a competitive inhibitor of the secreted (Group II) form of phospholipase A2.

YM-26734 is a competitive inhibitor of the secreted (Group II) form of phospholipase A2. The IC₅₀ against rabbit platelet derived sPLA2 is 85 nM. YM-26734 is active against, but less potent for group I (pancreatic) sPLA2 (porcine pancreatic enzyme IC₅₀ = 7 μM), and does not inhibit intracellular PLA2 isoforms.

YM-26734 is a natural product analog and a derivative of YM-26567-1, which is found in the fruit of Horsfieldia amygdaline. It exhibits a broad inhibitory spectrum towards different sPLA2s.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable