SML0603

Lixivaptan

≥96% (HPLC)

• Synonym(e): N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide, VPA 985, WAY-VPA 985
• Empirische Formel (Hill-System): C₂₇H₂₁ClFN₃O₂
• CAS-Nummer: 168079-32-1
• Molekulargewicht: 473.93
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥96% (HPLC)
• Form: powder

Eigenschaften

• description: 4% w/w in ethyl acetate
• Quality Segment: 100
• assay: ≥96% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: Fc1cc(c(cc1)C)C(=O)Nc2cc(c(cc2)C(=O)N3Cc4[n](ccc4)Cc5c3cccc5)Cl
• InChI: 1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
• InChI key: PPHTXRNHTVLQED-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.

Lixivaptan is an arginine vasopressin (AVP) V2-receptor antagonist.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable