SML0355

BCTC

≥98% (HPLC)

• Synonym(e): 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
• Empirische Formel (Hill-System): C₂₀H₂₅ClN₄O
• CAS-Nummer: 393514-24-4
• Molekulargewicht: 372.89
• NACRES: NA.77
• PubChem Substance ID: 329825357
• UNSPSC Code: 12352200
• MDL number: MFCD08690556
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >10 mg/mL
• storage temp.: room temp
• SMILES string: CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c3ncccc3Cl)cc1
• InChI: 1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
• InChI key: ROGUAPYLUCHQGK-UHFFFAOYSA-N

Beschreibung

Application

BCTC or (4-Tertbutylphenyl)-4-(3-chloropyridin-2-Yl) tetrahydropyrazine-1(2H)-carbox-amide has been used as transient receptor potential melastatin 8 (TRPM8) antagonist to study its effects on proliferation and cell viability.[1]

Biochem/physiol Actions

BCTC is a potent antagonist of the vanilloid receptor TRPV1.

BCTC is a potent antagonist of the vanilloid receptor TRPV1. BCTC blocks capsaicin-induced contractions in a variety of smooth muscle tissues, including guinea pig ileum, bladder and trachea with no effects on capsaicin-sensitive, sensory neuron-mediated positive inotropy. The compound penetrates the CNS and has strong analgesic properties.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable