SML0471

A22 hydrochloride

≥95% (HPLC), MreB inhibitor, powder

• Synonym(e): MreB Perturbing Compound A22, S-(3,4-Dichlorobenzyl)isothiourea hydrochloride
• Empirische Formel (Hill-System): C₈H₈Cl₂N₂S · HCl
• CAS-Nummer: 22816-60-0
• Molekulargewicht: 271.59
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825427
• NACRES: NA.77
• MDL number: MFCD00035050
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: A22 hydrochloride, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL (clear solution, warmed)
• storage temp.: 2-8°C
• SMILES string: Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1
• InChI: 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
• InChI key: VBJNMXMOMSWRDV-UHFFFAOYSA-N

Beschreibung

Application

A22 hydrochloride has been used to study its anti-biofilm activity, antibacterial, cyto and genotoxic activities. It is also used as a MreB polymerization inhibitor to understand the role of MreB polymers in Candidatus Thiosymbion oneisti and Candidatus T. hypermnestrae division.

Biochem/physiol Actions

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant.

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable