SML0350

AZD-7762 hydrochloride

≥98% (HPLC)

• Synonym(e): 5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride, AZD 7762 hydrochloride
• Empirische Formel (Hill-System): C₁₇H₁₉FN₄O₂S · HCl
• CAS-Nummer: 1246094-78-9
• Molekulargewicht: 398.88
• NACRES: NA.77
• PubChem Substance ID: 329825353
• UNSPSC Code: 12352200
• MDL number: MFCD12546135
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to light brown
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3
• InChI: 1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1
• InChI key: WFZBLOIXZRZEDG-YDALLXLXSA-N

Beschreibung

Application

AZD-7762 hydrochloride has been used:

• as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines[1]
• as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events[2]
• as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development[3]

Biochem/physiol Actions

AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.

AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2.

Sicherheitshinweise

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H318
• pcodes: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable