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Merck

SML0149

3-Ethoxy-5,6-dibromosalicylaldehyde

≥95% (HPLC)

Synonym(e):

2,3-Dibromo-5-ethoxy-6-hydroxy-benzaldehyde, 5,6-Dibromo-o-bourbonal

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Über diesen Artikel

Empirische Formel (Hill-System):
C9H8Br2O3
CAS-Nummer:
20041-64-9
Molekulargewicht:
323.97
NACRES:
NA.77
PubChem Substance ID:
329825197
UNSPSC Code:
12352200
MDL number:
MFCD00297095
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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InChI

1S/C9H8Br2O3/c1-2-14-7-3-6(10)8(11)5(4-12)9(7)13/h3-4,13H,2H2,1H3

SMILES string

CCOc1cc(Br)c(Br)c(C=O)c1O

InChI key

MZAISYPWQNBWED-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

yellow

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

Quality Level

100

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1 of 4

Dieser Artikel
SML1184D8446H9415
3-Ethoxy-5,6-dibromosalicylaldehyde ≥95% (HPLC)

Sigma-Aldrich

SML0149

3-Ethoxy-5,6-dibromosalicylaldehyde

OF-1 ≥98% (HPLC)

Sigma-Aldrich

SML1184

OF-1

P7C3 ≥98% (HPLC)

Sigma-Aldrich

D8446

P7C3

5HPP-33 ≥98% (HPLC), solid

Sigma-Aldrich

H9415

5HPP-33

form

powder

form

powder

form

powder

form

solid

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: ≥15 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 34 mg/mL

solubility

DMSO: >20 mg/mL

Application

3-Ethoxy-5,6-dibromosalicylaldehyde was used to study modulation of autophagy,[1] JNK activation[2] and NF-κB-mediated inflammation.[3]

Biochem/physiol Actions

3-Ethoxy-5,6-dibromosalicylaldehyde is a non-competitive inhibitor of Inositol-requiring enzyme 1 (IRE1). It inhibits XBP-1 splicing induced pharmacologically in human cells. 3-Ethoxy-5,6-dibromosalicylaldehyde potently inhibits the endoribonuclease of IRE1 but does not inhibit RNases A, T1, or L.
3-Ethoxy-5,6-dibromosalicylaldehyde is a non-competitive inhibitor of Inositol-requiring enzyme 1 (IRE1); potent inhibitor of endoribonuclease of IRE1

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H317

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000288833
0000288834
0000288834
0000288833
111M4733V

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Biochemical and biophysical research communications, 432(2), 326-332 (2013-02-12)
Hepatitis C virus (HCV) induces endoplasmic reticulum (ER) stress which, in turn, activates the unfolding protein response (UPR). UPR activates three distinct signalling pathways. Additionally, UPR induces autophagy (UPR-autophagy pathways). On the other hand, it has become clear that some
Yazhen Huo et al.
Virology, 444(1-2), 233-240 (2013-07-16)
Our previous study has shown that activation of JNK plays a critical role in Porcine reproductive and respiratory syndrome virus (PRRSV)-mediated apoptosis. In this follow-up study, we further investigated the mechanisms involved in modulation of PRRSV-mediated JNK activation and apoptosis.
Y Liu et al.
Apoptosis : an international journal on programmed cell death, 22(4), 544-557 (2017-02-12)
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