SML0081

Zacopride hydrochloride hydrate

≥98% (HPLC)

• Synonym(e): 4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride hydrate
• Empirische Formel (Hill-System): C₁₅H₂₀ClN₃O₂ · HCl · xH₂O
• CAS-Nummer: 101303-98-4
• Molekulargewicht: 346.25 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329825143
• UNSPSC Code: 12352200
• MDL number: MFCD20488057
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥10 mg/mL
• originator: Wyeth
• storage temp.: 2-8°C
• SMILES string: O.Cl.COc1cc(N)c(Cl)cc1C(=O)NC2CN3CC[C@H]2CC3
• InChI: 1S/C15H20ClN3O2.ClH.H2O/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19;;/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20);1H;1H2
• InChI key: NPXXKMBXEODDAF-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Serotonin 5-HT3 and 5-HT4 receptor antagonist

Zacopride is a sub-nanomolar antagonist of the serotonin 5-HT3 receptor that also displays agonist-like activity against 5-HT4 receptors. It is a potent anxiolytic in animal models, and also has strong antiemetic effects, and also increases aldosterone levels via activation of 5-HT4 receptor in the adrenal glands.

Features and Benefits

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable