The details of the manufacturing processing cannot be shared, for proprietary reasons, but the product is not sterile filtered.
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SBR00068
Streptomycin
Ready Made Solution, 100 mg/mL in water
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Unterstützung erhaltenQuality Segment
form
liquid, ready-to-use solution
specific activity
(Antibacterial)
concentration
100 mg/mL in water
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria
application(s)
advanced drug delivery
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
[S](=O)(=O)(O)O.[S](=O)(=O)(O)O.[S](=O)(=O)(O)O.N([C@@H]4[C@@H](O[C@H]([C@@H]([C@H]4O)O)CO)O[C@H]5[C@@H](O[C@H]([C@]5(O)C=O)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H]([C@@H]6O)O)N=C(N)N)O)N=C(N)N)C.N([C@@H]1[C@@H](O[C@H]([C@@H]([C@H]1O)O)CO)O[C@H]2[C@@H](O[C@H]([
InChI
1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-
InChI key
QTENRWWVYAAPBI-YZTFXSNBSA-N
General description
Chemical structure: aminoglycoside
Application
Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50 μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.
Biochem/physiol Actions
Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.
Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.
Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.
Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.
Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.
Preparation Note
- Streptomycin ready made solution contains 100 mg/mL streptomycin sulfate in water.
- Streptomycin: sulfate salt ratio is 1:1.5.
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Dieser Artikel | |||
|---|---|---|---|
| description Ready Made Solution, 100 mg/mL in water | description European Pharmacopoeia (EP) Reference Standard | description ~1 mg/mL in 1 mM EDTA, analytical standard | description powder, BioXtra, suitable for mouse embryo cell culture |
| specific activity (Antibacterial) | specific activity - | specific activity - | specific activity - |
| concentration 100 mg/mL in water | concentration - | concentration ~1 mg/mL in 1 mM EDTA | concentration - |
| form liquid, ready-to-use solution | form - | form liquid | form powder |
| antibiotic activity spectrum mycobacteria, Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum Gram-positive bacteria, Gram-negative bacteria, mycobacteria | antibiotic activity spectrum Gram-positive bacteria, mycobacteria, Gram-negative bacteria |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mode of action protein synthesis | interferes | mode of action - | mode of action protein synthesis | interferes | mode of action protein synthesis | interferes |
Signalwort
Warning
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Repr. 2
Lagerklasse
10 - Combustible liquids
Was ist los?
WGK 3
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Streptomycin ready made solution 100mg/ml cat # SBR00068 : is the solution filtered at the end of the preparation? Thank you
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