SBR00065

Rifampicin

Ready Made Solution, 50 mg/mL in DMSO

• Empirische Formel (Hill-System): C₄₃H₅₈N₄O₁₂
• CAS-Nummer: 13292-46-1
• Molekulargewicht: 822.94
• UNSPSC Code: 41116107
• NACRES: NA.76

Eigenschaften

• Quality Segment: 200
• form: liquid, ready-to-use solution
• specific activity: Antibacterial
• concentration: 50 mg/mL in DMSO
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycobacteria, viruses
• mode of action: protein synthesis | interferes
• storage temp.: −20°C
• SMILES string: N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O
• InChI: 1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
• InChI key: JQXXHWHPUNPDRT-WLSIYKJHSA-N

Beschreibung

General description

Rifampicin is a microlide antibiotic effective against gram-positive and gram-negative bacteria, mycobacteria and viruses.

Application

• Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.
• Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).
• Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.
• Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.

Biochem/physiol Actions

Inhibits the assembly of DNA and protein into mature virus particles.

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

Other Notes

The product is supplied in DMSO at a concentration of 50 mg/mL. Working concentrations for agrobacterium selection are typically 10-50 mg/L.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• flash_point_f: 188.6 °F - closed cup
• flash_point_c: 87 °C - closed cup