SAB5702250

Anti-CLDN18.2 Antibody, clone 3J4G7, Rabbit Monoclonal

• Synonym(e): CLDN18,SFTA5,SFTPJ
• UNSPSC-Code: 12352203
• NACRES: NA.46

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Materialien: colorless
• Klon: 3J4G7, monoclonal
• Form: liquid
• Speziesreaktivität: human
• Konzentration: 1.191 mg/mL
• Methode(n): immunohistochemistry: 1:50 - 1:200
• Farbe: colorless
• Isotyp: IgG
• UniProt-Hinterlegungsnummer: P56856
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CLDN18.2(51208)

Beschreibung

Allgemeine Beschreibung

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Immunogen

A synthetic peptide of human CLDN18.2.

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

Anwendung

IHC

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H317,H411
• P-Sätze: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Gefahreneinstufungen: Aquatic Chronic 2 - Skin Sens. 1
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3