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Merck

SAB4502029

Sigma-Aldrich

Anti-NPY2R antibody produced in rabbit

affinity isolated antibody

Synonym(e):

NPY-Y2 receptor, NPY2-R, NPY2R, Neuropeptide Y receptor type 2

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 42 kDa

Speziesreaktivität

human, mouse, rat

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... NPY2R(4887)

Verwandte Kategorien

Allgemeine Beschreibung

The NPY2R (neuropeptide Y receptor Y2) gene is mapped to human chromosome 4q32.1 and codes for a G-protein-coupled receptor. NPY2R is predominantly expressed in central nervous system including hypothalamus, brain stem, hippocampus, lateral septum and amygdala. NPY2 receptors are also distributed in the liver, spleen, intestine, adipose tissue and muscle.

Immunogen

The antiserum was produced against synthesized peptide derived from human NPY2R.

Immunogen Range: 1-50

Biochem./physiol. Wirkung

NPY2R (neuropeptide Y receptor Y2) acts as a presynaptic autoreceptor and heteroreceptor. It regulates the release of both endogenous NPY and neurotransmitters such as glutamate and γ–aminobutyric acid (GABA). NPY exerts its anxiolytic function via the NPY2R. Deletion of NPY2R results in retardation of the anticonvulsant actions of NPY. NPY2R plays an important role in the process of bone formation.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Debanjan Chakroborty et al.
British journal of cancer, 127(8), 1440-1449 (2022-07-29)
Resistance to anti-angiogenic therapies targeting vascular endothelial growth factor-A (VEGF-A) stems from VEGF-A independent angiogenesis mediated by other proangiogenic factors. Therefore identifying these factors in colon adenocarcinoma (CA) will reveal new therapeutic targets. Neuropeptide Y (NPY) and Y2 receptor (Y2R)
Viswanthram Palanivel et al.
Cells, 11(22) (2022-11-27)
Neuropeptide Y (NPY), a sympathetic neurotransmitter, is involved in various physiological functions, and its dysregulation is implicated in several neurodegenerative diseases. Glutamate excitotoxicity, endoplasmic reticulum (ER) stress, and oxidative stress are the common mechanisms associated with numerous neurodegenerative illnesses. The
Gopi Kumar Mittapalli et al.
Bioorganic & medicinal chemistry letters, 24(2), 430-441 (2013-12-25)
Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian brain and exerts a variety of physiological processes in humans via four different receptor subtypes Y1, Y2, Y4 and Y5. Y2 receptor is the most abundant Y
Yuka Akagi et al.
FEBS open bio, 14(1), 63-78 (2023-11-28)
Food-derived biological signals are transmitted to the brain via peripheral nerves through the paracrine activity of gastrointestinal (GI) hormones. The signal transduction circuit of the brain-gut axis has been analyzed in animals; however, species-related differences and animal welfare concerns necessitate
Tao Yang et al.
Cellular & molecular biology letters, 28(1), 60-60 (2023-07-28)
Sebaceous glands (SGs) synthesize and secret sebum to protect and moisturize the dermal system via the complicated endocrine modulation. Dysfunction of SG are usually implicated in a number of dermal and inflammatory diseases. However, the molecular mechanism behind the differentiation

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