R3905

Ro273225 -trifluoracetat (Salz)

≥98% (reversed phase HPLC)

• Synonym(e): Butir-His-D-Phe-Arg-Trp-Sar-NH2 -trifluoracetat (Salz)
• Empirische Formel (Hill-System): C₃₉H₅₂N₁₂O₆ · xC₂HF₃O₂
• CAS-Nummer: 1057258-86-2
• Molekulargewicht: 784.91 (free base basis)
• NACRES: NA.77
• PubChem Substance ID: 329824026
• UNSPSC Code: 51111800
• MDL number: MFCD04112656
• Assay: ≥98% (reversed phase HPLC)
• Form: lyophilized solid

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (reversed phase HPLC)
• form: lyophilized solid
• color: white
• solubility: H₂O: >10 mg/mL
• storage temp.: room temp
• SMILES string: CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)CC(N)=O
• InChI: 1S/C39H52N12O6/c1-3-10-34(53)47-31(19-26-21-43-23-46-26)37(56)49-30(17-24-11-5-4-6-12-24)36(55)48-29(15-9-16-44-39(41)42)35(54)50-32(38(57)51(2)22-33(40)52)18-25-20-45-28-14-8-7-13-27(25)28/h4-8,11-14,20-21,23,29-32,45H,3,9-10,15-19,22H2,1-2H3,(H2,40,52)(H,43,46)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H4,41,42,44)/t29-,30-,31-,32-/m0/s1
• InChI key: NINOPZAAGJJNAR-YDPTYEFTSA-N

Beschreibung

Biochem/physiol Actions

Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.

Ro 27-3225 is a selective melanocortin MC₄ receptor agonist.

Features and Benefits

This compound is featured on the Melanocortin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)