R3655

Rubitecan

powder, ≥98% (HPLC)

• Synonym(e): 9-nitrocamptothecin
• Empirische Formel (Hill-System): C₂₀H₁₅N₃O₆
• CAS-Nummer: 91421-42-0
• Molekulargewicht: 393.35
• UNSPSC Code: 12352204
• PubChem Substance ID: 329824025
• NACRES: NA.77
• MDL number: MFCD06656294

Eigenschaften

• Produktname: Rubitecan,
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• mp: 182-186 °C
• solubility: DMSO: 1 mg/mL
• storage temp.: room temp
• SMILES string: CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5c(cccc5nc34)[N+]([O-])=O)C2=O
• InChI: 1S/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1
• InChI key: VHXNKPBCCMUMSW-FQEVSTJZSA-N

Beschreibung

Biochem/physiol Actions

Topoisomerase I inhibitor. Rubitecan induces protein- linked DNA single strand breaks, blocking DNA and RNA synthesis in dividing cells. This mode of action makes rubitecan a potential chemotherapeutic agent, and it has been used with some success against refractory pancreatic cancer.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)