Q0875

Chinidin -sulfat (Salz) Dihydrat

potassium channel blocker

• Empirische Formel (Hill-System): C₄₀H₄₈N₄O₄ · H₂O₄S · 2H₂O
• CAS-Nummer: 6591-63-5
• Molekulargewicht: 782.94
• NACRES: NA.77
• PubChem Substance ID: 24277870
• UNSPSC Code: 12352200
• EC Number: 200-046-3
• MDL number: MFCD00149346

Eigenschaften

• Produktname: Chinidin -sulfat (Salz) Dihydrat,
• Quality Segment: 200
• impurities: ≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
• mp: 212-214 °C (dec.) (lit.)
• originator: Bayer
• SMILES string: [H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
• InChI key: ZHNFLHYOFXQIOW-WFTMRWCJSA-N

Beschreibung

General description

Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.

Application

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves