O3639

Ondansetron -hydrochlorid Dihydrat

≥98% (HPLC), powder, 5-HT₃serotonin receptor antagonist

• Synonym(e): 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)-methyl]-4H-carbazol-4-on -hydrochlorid Dihydrat, GR 38032F
• Empirische Formel (Hill-System): C₁₈H₁₉N₃O · HCl · 2H₂O
• CAS-Nummer: 103639-04-9
• Molekulargewicht: 365.85
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818907
• NACRES: NA.32
• MDL number: MFCD00374371
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: Ondansetron -hydrochlorid Dihydrat, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white
• solubility: H₂O: >5 mg/mL
• storage temp.: −20°C
• SMILES string: Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C
• InChI: 1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2
• InChI key: VRSLTNZJOUZKLX-UHFFFAOYSA-N
• Gene Information: human ... HTR3A(3359)

Beschreibung

Application

Ondansetron hydrochloride dihydrate has been used as a 5-HT₃ antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT₃ protein.

Biochem/physiol Actions

Ondansetron, (3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl] 1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dehydrate acts as a selective 5-hydroxytryptamine type 3 (5-HT3) serotonin receptor antagonist. It is used as an antiemetic to control nausea and vomiting associated with chemotherapy and radiotherapy.

5-HT₃ Serotonin-Rezeptor-Antagonist

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS06,GHS05,GHS09
• signalword: Danger
• hcodes: H301,H318,H410
• pcodes: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P391
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges