O3636

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

powder

• Synonym(e): ODQ
• Empirische Formel (Hill-System): C₉H₅N₃O₂
• CAS-Nummer: 41443-28-1
• Molekulargewicht: 187.15
• NACRES: NA.32
• PubChem Substance ID: 24278054
• UNSPSC Code: 41106305
• MDL number: MFCD00792620

Eigenschaften

• assay: ≥98% (TLC)
• Quality Segment: 200
• form: powder
• color: pale yellow
• solubility: ethanol: 1.2 mg/mL, DMSO: 5 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: O=C1ON=C2C=Nc3ccccc3N12
• InChI: 1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
• InChI key: LZMHWZHOZLVYDL-UHFFFAOYSA-N
• Gene Information: human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Beschreibung

Application

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one has been used as a oxidising agent for  affinity selection-mass spectrometry (AS-MS) compound binding assay, as a soluble guanylate cyclase (sGC) inhibitor to inhibit S-nitroso-N-acetyl-DL-penicillamine (SNAP)-induced cGMP production.

Biochem/physiol Actions

H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.

Selective inhibitor of nitric oxide-sensitive guanylyl cyclase.

Disclaimer

Hygroscopic

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves