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O001

β-Chlornaltrexamine dihydrochloride

solid

Synonym(e):

β-CNA

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Über diesen Artikel

Empirische Formel (Hill-System):
C24H32Cl2N2O3 · 2HCl
CAS-Nummer:
67025-98-3
Molekulargewicht:
540.35
UNSPSC Code:
12352116
PubChem Substance ID:
24897920
NACRES:
NA.77
Form:
solid
Quality level:
100

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form

solid

Quality Level

100

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white

solubility

H2O: soluble (use aqueous solutions immediately.), ethanol: soluble (is stable for ca. 1 month in the freezer.), polar organic solvents: soluble

storage temp.

−20°C

SMILES string

Cl.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)N(CCCl)CCCl)CC6CC6

InChI

1S/C24H32Cl2N2O3.2ClH/c25-8-11-27(12-9-26)17-5-6-24(30)19-13-16-3-4-18(29)21-20(16)23(24,22(17)31-21)7-10-28(19)14-15-1-2-15;;/h3-4,15,17,19,22,29-30H,1-2,5-14H2;2*1H/t17-,19-,22+,23+,24-;;/m1../s1

InChI key

JJZDLJGFHABVOM-QNWHWJQFSA-N

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1 of 4

Dieser Artikel
O003B016525276
β-Chlornaltrexamine dihydrochloride solid

Sigma-Aldrich

O001

β-Chlornaltrexamine dihydrochloride

β-Funaltrexamine hydrochloride solid

Sigma-Aldrich

O003

β-Funaltrexamine hydrochloride

Benoxathian hydrochloride solid

Sigma-Aldrich

B016

Benoxathian hydrochloride

Phosphoramidon, Disodium Salt Inhibits some metalloendopeptidases.

Sigma-Aldrich

525276

Phosphoramidon, Disodium Salt

form

solid

form

solid

form

solid

form

lyophilized solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

-

drug control

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: soluble (use aqueous solutions immediately.), polar organic solvents: soluble, ethanol: soluble (is stable for ca. 1 month in the freezer.)

solubility

H2O: 7.5 mg/mL (aqueous solutions should be promptly used), methanol: 7.6 mg/mL (do not store in ethanolic solution; methanolic solutions may be stored for several weeks at 4 °C)

solubility

H2O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.), ethanol: soluble, isopropanol: soluble

solubility

DMSO: 10 mg/mL, methanol: soluble, water: soluble

color

white

color

white

color

white

color

white

Biochem/physiol Actions

Irreversible μ, δ and κ opioid receptor antagonist.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Hygroscopic, photosensitive.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
061K4606

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Die Dokumentenbibliothek aufrufen

T P Caruso et al.
The Journal of pharmacology and experimental therapeutics, 213(3), 539-544 (1980-06-01)
The 6-bis(2)chloroethyl)amino derivatives of oxymorphone and naltrexone, chloroxymorphamine (COA) and chlornaltrexamine (CNA), respectively, produce an irreversible inhibition of [3H]naltrexone binding to mouse brain homogenates. Intracerebroventricular (i.c.v.) injection of COA (4 nmol/mouse) elicits analgesia which lasts 4 times longer than analgesia
Leon W Fyfe et al.
The Journal of pharmacology and experimental therapeutics, 335(3), 674-680 (2010-08-27)
Opioids activate the descending antinociceptive pathway from the ventrolateral periaqueductal gray (vlPAG) by both pre- and postsynaptic inhibition of tonically active GABAergic neurons (i.e., disinhibition). Previous research has shown that short-term desensitization of postsynaptic μ-opioid receptors (MOPrs) in the vlPAG
S J Ward et al.
European journal of pharmacology, 80(4), 377-384 (1982-06-04)
The profiles of action of beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) have been assessed in the mouse vas deferens preparation. beta-FNA, but not beta-CNA, demonstrated a reversible agonist action that appeared to be mediated via kappa-receptor interaction. beta-CNA produced an irreversible
Michael S Virk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(22), 7341-7348 (2009-06-06)
Buprenorphine is a weak partial agonist at mu-opioid receptors that is used for treatment of pain and addiction. Intracellular and whole-cell recordings were made from locus ceruleus neurons in rat brain slices to characterize the actions of buprenorphine. Acute application
W Kozak et al.
Physiology & behavior, 58(2), 353-362 (1995-08-01)
The effects of an irreversible long term opioid antagonism on circadian rhythms in body temperature (Tb), locomotor activity (Act) and feeding under normal conditions and following lipopolysaccharide administration (LPS; 2.5 mg/kg) have been investigated in unrestrained mice housed at their
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Global Trade Item Number

SKUGTIN
O001-5MG04061832557632
O001-1MG04061826203538

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