N5148

Nodularin

From microbial, ≥94% (TLC), PP2A inhibitor, film or powder

• Synonym(e): 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
• Empirische Formel (Hill-System): C₄₁H₆₀N₈O₁₀
• CAS-Nummer: 118399-22-7
• Molekulargewicht: 824.96
• UNSPSC Code: 12352202
• PubChem Substance ID: 329818653
• NACRES: NA.77
• MDL number: MFCD16659855

Eigenschaften

• Produktname: Nodularin, cyanotoxin
• biological source: microbial
• Quality Segment: 200
• assay: ≥94% (TLC)
• form: film or powder
• solubility: methanol: 2 mg/mL (Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.)
• storage temp.: 2-8°C
• SMILES string: CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(C)\C=C\[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)\C(=C\C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]2C)C(O)=O)C(O)=O
• InChI: 1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8-/t24-,25-,26-,28-,29-,30+,32-,34+/m0/s1
• InChI key: IXBQSRWSVIBXNC-HSKGSTCASA-N

Beschreibung

General description

Nodularin is a cyclic pentapeptide toxin produced by the cyanobacteria Nodularia spumigena.

Application

Nodularin has been used to induce oxidative stress and analyse its dynamics in flounder liver. It has also been used as standard for identification and quantification by high performance liquid chromatography (HPLC).

Biochem/physiol Actions

Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model.; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H310 + H330,H315,H317,H319,H335
• pcodes: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable