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Dokumente

M6807

Sigma-Aldrich

Misoprostol

≥99% (HPLC)

Synonym(e):

(±)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1-methylester

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About This Item

Empirische Formel (Hill-System):
C22H38O5
CAS-Nummer:
59122-46-2
Molekulargewicht:
382.53
MDL-Nummer:
MFCD00274550
UNSPSC-Code:
12352211
PubChem Substanz-ID:
24897117
NACRES:
NA.77

Qualitätsniveau

200

Assay

≥99% (HPLC)

Form

liquid

Funktionelle Gruppe

ester

Lagertemp.

−20°C

SMILES String

CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC

InChI

1S/C22H38O5/c1-4-5-14-22(2,26)15-10-12-18-17(19(23)16-20(18)24)11-8-6-7-9-13-21(25)27-3/h10,12,17-18,20,24,26H,4-9,11,13-16H2,1-3H3/b12-10+/t17-,18-,20-,22?/m1/s1

InChIKey

OJLOPKGSLYJEMD-URPKTTJQSA-N

Angaben zum Gen

human ... PTGER3(5733) , PTGIR(5739)

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Verwandte Kategorien

Biochem./physiol. Wirkung

PGE1 analog prodrug which is rapidly de-esterified to active "misoprostolic acid". Cited for extremely wide-ranging therapeutic effects, including prevention of NSAID-induced gastric ulceration, regulation of immunologic cascades, inhibition of platelet-activating factor (PAF), treatment of ethanol- and acetaminophen-induced hepatotoxicity and hepatitis, and stimulation of cartilage repair after injury.
Cytoprotective PGE1 analog that prevents NSAID-induced gastric ulceration.

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

H-Sätze

H301,H360

Gefahreneinstufungen

Acute Tox. 3 Oral - Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Prostaglandin E1 ≥98% (HPLC), synthetic

Sigma-Aldrich

P5515

Prostaglandin E1

Misoprostol für die Systemeignung European Pharmacopoeia (EP) Reference Standard

Y0001162

Misoprostol für die Systemeignung

Carboprosttromethamin United States Pharmacopeia (USP) Reference Standard

USP

1096509

Carboprosttromethamin

Ingrid Sääv et al.
Human reproduction (Oxford, England), 30(6), 1314-1322 (2015-04-04)
Can sublingual administration of misoprostol 1 h prior to vacuum aspiration be more effective than vaginal administration and as effective as either route three 3 h prior to surgery? Sublingually administered misoprostol is superior to vaginally administered misoprostol when given
Christina S Chu et al.
Journal of the Royal Society of Medicine, 105(8), 336-347 (2012-08-22)
This article describes and critically appraises clinical trials assessing misoprostol effectiveness in preventing primary postpartum haemorrhage (PPH) in home and community settings in low- and middle-income countries. Of 172 identified studies of misoprostol use in labour only six fulfilled the
V A Hundley et al.
BJOG : an international journal of obstetrics and gynaecology, 120(3), 277-285 (2012-11-30)
Using misoprostol to prevent postpartum haemorrhage (PPH) in home-birth settings remains controversial. To review the safety and effectiveness of oral misoprostol in preventing PPH in home-birth settings. The Cochrane Library, PubMed, and POPLINE were searched for articles published until 31
D Y Graham et al.
Lancet (London, England), 2(8623), 1277-1280 (1988-12-03)
A double-blind, placebo-controlled study was carried out to see whether the synthetic E prostaglandin, misoprostol, would prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). 420 patients with osteoarthritis and NSAID-associated abdominal pain were studied; they were receiving ibuprofen, piroxicam
N Bernard et al.
BJOG : an international journal of obstetrics and gynaecology, 120(5), 568-574 (2013-01-26)
To report the follow-up of continuing pregnancies after first-trimester exposure to mifepristone. Observational prospective study. France. Patients exposed to mifepristone during the first 12 weeks of pregnancy. Women were included in the study when they or their doctors asked a
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