L9756

(−)-Tetramisol -hydrochlorid

powder, ≥99% (GC)

• Synonym(e): (S)-(−)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazol -hydrochlorid, L(−)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazol -hydrochlorid, Levamisol -hydrochlorid
• Empirische Formel (Hill-System): C₁₁H₁₂N₂S · HCl
• CAS-Nummer: 16595-80-5
• Molekulargewicht: 240.75
• NACRES: NA.77
• PubChem Substance ID: 24278526
• UNSPSC Code: 12352202
• EC Number: 240-654-6
• MDL number: MFCD00012675
• Beilstein/REAXYS Number: 4358988

Eigenschaften

• Produktname: (−)-Tetramisol -hydrochlorid, ≥99% (GC)
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥99% (GC)
• form: powder
• input: mammalian sample(s)
• mp: 228-230 °C
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• antibiotic activity spectrum: parasites
• mode of action: enzyme | inhibits
• SMILES string: Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3
• InChI: 1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
• InChI key: LAZPBGZRMVRFKY-HNCPQSOCSA-N

Beschreibung

Application

Suitable for inhibition of various mammalian alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor).
Intestinal alkaline phosphatases are only slightly inhibited.
Not for veterinary use.

Biochem/physiol Actions

Zeigt sowohl immunstimulierende als auch immunsuppressive Wirkungen, abhängig von verschiedenen steuerbaren Faktoren. Sehr wirksam bei der Behandlung von Ascariasis (Hakenwürmer Befall). Nützlich in der Chemotherapie von kolorektalen Karzinomen, möglicherweise aufgrund seiner Stimulation der IL-1 Produktion und direkter Aktivierung von Makrophagen.

Other Notes

Levamisole hydrochloride is soluble in water at 50mg/mL yielding a clear, colorless solution. Solutions are stable at 2-8°C for ~1 month.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges