L2774

Lincomycin -hydrochlorid

suitable for cell culture, BioReagent

• Synonym(e): Lincocin -hydrochlorid
• Empirische Formel (Hill-System): C₁₈H₃₄N₂O₆S · HCl
• CAS-Nummer: 859-18-7
• Molekulargewicht: 443.00
• NACRES: NA.76
• PubChem Substance ID: 329817401
• UNSPSC Code: 12352207
• EC Number: 212-726-7
• MDL number: MFCD00083647
• Beilstein/REAXYS Number: 4171650

Eigenschaften

• Produktname: Lincomycin -hydrochlorid, BioReagent, suitable for cell culture
• product line: BioReagent
• Quality Segment: 200
• potency: 800-900 units per mg
• technique(s): cell culture | mammalian: suitable
• color: white to yellow-white
• solubility: H₂O: 4 mL, clear, colorless to faintly yellow (200 mg + 4 mL H2O)
• antibiotic activity spectrum: Gram-positive bacteria
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O
• InChI: 1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1
• InChI key: POUMFISTNHIPTI-BOMBIWCESA-N

Beschreibung

General description

Chemical structure: macrolide

Application

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance and protein and surfactant binding. It is produced by Streptomyces lincolnensis var. lincolnensis, and has been used in the treatment of Staphylococcal, Streptococcal, and Bacterioides fragilis infections.

Biochem/physiol Actions

Lincomycin ist ein Antibiotikum aus der Gruppe der Lincosamide, welches Quervernetzungen in der Peptidyltransferase-Loop-Region der 23S rRNA erzeugt.
Wirkmechanismus: inhibiert die bakterielle Proteinsynthese
Antimicrobielles Spektrum: Gram-positive Bakterien.

Preparation Note

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves