H5915

2,3-Bis(4-hydroxyphenyl)propionitrile

≥98% (HPLC), estrogen receptor β agonist, powder

• Synonym(e): DPN, Diarylpropionitrile, SC-4473
• Empirische Formel (Hill-System): C₁₅H₁₃NO₂
• CAS-Nummer: 1428-67-7
• Molekulargewicht: 239.27
• UNSPSC Code: 51111800
• PubChem Substance ID: 329815224
• NACRES: NA.77
• MDL number: MFCD01695412
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: 2,3-Bis(4-hydroxyphenyl)propionitrile, ≥98% (HPLC)
• sterility: non-sterile
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
• InChI: 1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
• InChI key: GHZHWDWADLAOIQ-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

2,3-Bis(4-hydroxyphenyl)-propionitrile (Diarylprepionitrile, DPN) is an ERβ-selective agonist; IC₅₀ = 15nM. DPN protects WT and ARKO mice and significantly decreases IL-1β following LPS treatment in young adult-derived microglia. PPT (Cat. No.H6036, ERa agonist) enhances cell proliferation, while DPN inhibits it. PPT increases Bcl-2 expression, while DPN decreases it. DPN also elevates Bax expression. DPN induces a dose-dependent increase on vitellogenin synthesis. PPT and DPN are effective in dynamically, but differentially regulating intracellular calcium signaling in hippocampal neurons. DPN is more efficacious than PPT in potentiating a physiological concentration of glutamate-induced intracellular Ca²⁺ rise in these neurons. DPN prevents the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.

2,3-Bis(4-hydroxyphenyl)-propionitrile is an ERβ-selective agonist; IC₅₀ = 15nM.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• Gefahrencodes: H319,H400
• Sicherheitshinweise: P273 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves