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G6013

L-Glutathion reduziert

≥98.0%, suitable for cell culture, BioReagent

Synonym(e):

γ-L-Glutamyl-L-cysteinyl-glycin, GSH

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Größe/SKUVerfügbarkeitPreis
5 g
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€ 146,00
10 g
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€ 264,00
25 g
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100 g
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Über diesen Artikel

Lineare Formel:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
CAS-Nummer:
Molekulargewicht:
307.32
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-725-4
MDL number:
Beilstein/REAXYS Number:
1729812

€ 146,00


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Produktname

L-Glutathion reduziert, suitable for cell culture, BioReagent, ≥98.0%, powder

product line

BioReagent

Quality Segment

assay

≥98.0%

form

powder

technique(s)

cell culture | mammalian: suitable

color

white

mp

192-195 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

storage temp.

2-8°C

SMILES string

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChI key

RWSXRVCMGQZWBV-WDSKDSINSA-N

Application

In einer Konzentration von 5–10 mM kann es verwendet werden, um Glutathion-S-Transferase (GST) aus Glutathion-Agarose zu eluieren.

Biochem/physiol Actions

Endogenes Antioxidans, das eine wesentliche Rolle bei der Reduktion von im Zellstoffwechsel und beim „oxidativen Burst“ gebildeten reaktiven Sauerstoffspezies spielt. Glutathion-S-Transferase katalysiert die Bildung von Glutathionthioethern mit Xenobiotika, Leukotrienen und anderen Molekülen mit einem elektrophilen Zentrum. Weiterhin bildet Glutathion in Proteinen Disulfidbindungen mit Cysteinresten. Aufgrund dieser Mechanismen kann es den paradoxen Effekt haben, die Wirkung von Antikrebsmitteln zu verringern.

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Dieser Artikel
G4251G6529Y0000517
Glutathion European Pharmacopoeia (EP) Reference Standard

Y0000517

Glutathion

description

suitable for cell culture, BioReagent, ≥98.0%, powder

description

≥98.0%

description

BioXtra, ≥98.0%

description

European Pharmacopoeia (EP) Reference Standard

form

powder

form

powder

form

powder

form

-

assay

≥98.0%

assay

≥98.0%

assay

≥98.0%

assay

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

product line

BioReagent

product line

-

product line

BioXtra

product line

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mp

192-195 °C (dec.) (lit.)

mp

192-195 °C (dec.) (lit.)

mp

192-195 °C (dec.) (lit.)

mp

192-195 °C (dec.) (lit.)


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Lagerklasse

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–6 of 6 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the GSH level in plasma?

    1 answer
    1. It is in the micromolar range (approximately 4.5 mM). Chawla RK, Lewis FW, Kutner MH, et al. Plasma cysteine, cysteine, and glutathione in cirrhosis. Gastroenterology, 87, 770-776 (1984).

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  5. What are the GSH levels in human tissues?

    1 answer
    1. The GSH levels in human tissues normally range from 0.1 to 10 mM, most concentrated in the liver (up to 10 mM) and in the spleen, kidney, lens, erythrocytes, and leukocytes. Bremer HJ. Duran M, Kamerling JP, et al. Glutathione. In: Bremer HJ,DuranM, Kamerling JP, et al, eds. Distubance of Amino Acid Metabolism: Clinical Chemistry and Diagnosis. Baltimore-Munich: Urban and Schwarzenber; 1981:80-82.

      Helpful?

  6. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

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