G5168

(Z)-Guggulsteron

≥89% (HPLC), bile acid receptor antagonist, powder

• Synonym(e): (17Z)-Pregna-4,17(20)-dien-3,16-dion, 4,17(20)-trans-Pregnadien-3,16-dion
• Empirische Formel (Hill-System): C₂₁H₂₈O₂
• CAS-Nummer: 39025-23-5
• Molekulargewicht: 312.45
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278392
• NACRES: NA.77
• MDL number: MFCD01310757
• Assay: ≥89% (HPLC)
• Form: powder

Eigenschaften

• Produktname: (Z)-Guggulsteron, ≥89% (HPLC), powder
• Quality Segment: 200
• assay: ≥89% (HPLC)
• form: powder
• technique(s): HPLC: suitable, chromatography: suitable, gas chromatography (GC): suitable
• impurities: ≤5.4% E-form
• color: light yellow
• solubility: DMSO: 5 mg/mL
• application(s): forensics and toxicology; veterinary
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)\C(=C\C)C(=O)C[C@@]24[H]
• InChI: 1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
• InChI key: WDXRGPWQVHZTQJ-OSJVMJFVSA-N

Beschreibung

Biochem/physiol Actions

(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.

(Z)-Guggulsterone is an antagonist ligand for bile acid receptor.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H335
• Sicherheitshinweise: P261 - P271 - P304 + P340 + P312 - P403 + P233 - P405 - P501
• Hazard Classifications: STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves