G4919

Goserelinacetat

≥99% (HPLC), white, powder

• Synonym(e): [D-Ser(tBu)⁶,Azagly¹⁰]-LHRH -acetat (Salz)
• Empirische Formel (Hill-System): C₅₉H₈₄N₁₈O₁₄
• CAS-Nummer: 145781-92-6
• Molekulargewicht: 1269.41
• NACRES: NA.32
• PubChem Substance ID: 329799933
• UNSPSC Code: 51111800
• MDL number: MFCD01747329
• Assay: ≥99% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 200
• assay: ≥99% (HPLC)
• form: powder
• color: white
• solubility: H₂O: 20 mg/mL, clear, colorless
• UniProt accession no.: P55248, P01148, P07490, P13562, P30968, P30969, Q01776
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CC(O)=O.CC(C)C[C@H](NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)NNC(N)=O
• InChI: 1S/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1
• InChI key: IKDXDQDKCZPQSZ-JHYYTBFNSA-N
• Gene Information: human ... GNRH1(2796), GNRHR(2798) ; mouse ... GNRH1(14714), GNRHR(14715) ; rat ... GNRH1(25194), GNRHR(81668) ;

Beschreibung

General description

Goserelin acetate is a synthetic decapaptide, which is a potent analog of LHRH (luteinizing hormone releasing hormone).

Goserelin is used to guard ovary during breast-cancer adjuvant chemotherapy.

Biochem/physiol Actions

Goserelin acetate peptide results in significant inhibition of gonadotropin release and suppresses steroidogenesis in ovaries and testis. Thus, it leads to a reduction of testosterone to castration levels and estrogen to postmenopausal levels. Therefore, this peptide is used for reducing testosterone levels in patients with locally advanced prostate cancer.

Goserelin ist ein synthetisches Analogon des LHRH (luteinisierendes Hormon Releasing-Hormon) und ein LHRH-Agonist. Es wird bei der Therapie von Prostatakrebs und Brustkrebs, sowie der Behandlung von Endometriose angewendet.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• Gefahrencodes: H360
• Sicherheitshinweise: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)