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Merck

F6127

Fludrocortisonacetat

synthetic, ≥98%, glucocorticoid activity, powder

Synonym(e):

9α-Fluor-11β,17α,21-trihydroxy-4-pregnen-3,20-dion-acetat, 9-Fluor-hydrocortison-acetat, 9-Fluorcortisol-acetat

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€ 82,60

5 G

€ 278,80

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Über diesen Artikel

Empirische Formel (Hill-System):
C23H31FO6
CAS-Nummer:
514-36-3
Molekulargewicht:
422.49
NACRES:
NA.77
PubChem Substance ID:
24894899
UNSPSC Code:
12352200
EC Number:
208-180-4
MDL number:
MFCD00864160
Assay:
≥98%
Form:
powder
Quality level:
100

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Produktname

Fludrocortisonacetat, ≥98%

biological source

synthetic

Quality Level

100

sterility

non-sterile

assay

≥98%

form

powder

solubility

acetone: 50 mg/mL, clear, colorless to light yellow

shipped in

ambient

storage temp.

room temp

SMILES string

CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C

InChI

1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1

InChI key

SYWHXTATXSMDSB-GSLJADNHSA-N

Gene Information

human ... NR3C2(4306)

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Dieser Artikel
F01800001273003BP159
Fludrocortisone acetate ≥98%

Sigma-Aldrich

F6127

Fludrocortisone acetate

Fludrocortisone acetate European Pharmacopoeia (EP) Reference Standard

F0180000

Fludrocortisone acetate

Fludrocortisone acetate United States Pharmacopeia (USP) Reference Standard

USP

1273003

Fludrocortisone acetate

Fludrocortisone acetate British Pharmacopoeia (BP) Reference Standard

BP159

Fludrocortisone acetate

form

powder

form

-

form

-

form

solid

assay

≥98%

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

acetone: 50 mg/mL, clear, colorless to light yellow

solubility

-

solubility

-

solubility

-

shipped in

ambient

shipped in

-

shipped in

-

shipped in

-

General description

Fludrocortisone acetate is secreted by adrenal cortex. It increases the reabsorption of sodium and secretion of potassium and hydrogen. Fludrocortisone is used to treat cerebral salt wasting syndrome and adrenal insufficiency. Fludrocortisone improves the sensitivity of blood vessels to catecholamines and increases the blood volume.

Biochem/physiol Actions

Fludrocortisone acetate is a synthetic corticosteroid with more mineralocorticoid than glucocorticoid activity.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H361

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCG3165
BCBV4395
BCBR1170V
BCBR1170
BCBQ4707V

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Die Dokumentenbibliothek aufrufen

Dong-Min Kim et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 22(11), 3273-3276 (2007-07-10)
Hyperkalaemia is a commonly encountered problem in dialysis patients with end-stage renal disease (ESRD). The aim of the present study was to assess the effect of fludrocortisone acetate (FCA) on reducing serum potassium levels in haemodialysis (HD) patients with hyperkalaemia.
R Taniguchi et al.
The Tohoku journal of experimental medicine, 186(3), 215-223 (1999-05-29)
It is known that some patients with primary aldosteronism show postoperative hyperkalemia, which is due to inability of the adrenal gland to secrete sufficient amounts of aldosterone. However, hyperkalemia is generally neither severe nor prolonged, in which replacement therapy with
Clinical Pharmacology Made Incredibly Easy! (2009)
Stéphane Gibaud et al.
International journal of pharmaceutics, 269(2), 491-508 (2004-01-07)
Substitutive hormonal therapies have to be administered for long periods. Thus, the development of sustained-release forms, as microparticle suspensions, is interesting in order to improve patient compliance by reducing dosing frequencies and side effects. The aim of this work was
Aruna V Krishnan et al.
Endocrinology, 143(5), 1889-1900 (2002-04-17)
The cortisol/cortisone-responsive AR (AR(ccr)) has two mutations (L701H and T877A) that were found in the MDA PCa human prostate cancer cell lines established from a castrated patient whose metastatic tumor exhibited androgen-independent growth. Cortisol and cortisone bind to the AR(ccr)
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Verwandter Inhalt

Global Trade Item Number

SKUGTIN
F6127-1G04061826236581
F6127-5G04061832850153

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