G4796

Genipin

≥98% (HPLC), powder, insulin stimulator

• Synonym(e): 1S,2R,6S)-2-Hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-dien-5-carbonsäure-methylester
• Empirische Formel (Hill-System): C₁₁H₁₄O₅
• CAS-Nummer: 6902-77-8
• Molekulargewicht: 226.23
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799931
• NACRES: NA.77
• MDL number: MFCD00888600
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Genipin, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: ≥25 mg/mL, H₂O: insoluble
• SMILES string: COC(=O)C1=CO[C@@H](O)C2C1CC=C2CO
• InChI: 1S/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3/t7-,9-,11-/m1/s1
• InChI key: AZKVWQKMDGGDSV-BCMRRPTOSA-N

Beschreibung

General description

Genipin is a natural cross linking agent, which is extracted from gardenia fruit. It prevents lipid peroxidation and production of nitric oxide. Genipin protects the hippocampal neurons from the toxicity of Alzheimer′s amyloid β protein. It has anti-inflammatory and anti-angiogenesis effects. Genipin is involved in drug delivery system.

Application

Genipin has been used:

• in chemosensitivity assay
• in the preparation of recombinant human (rh)-odontogenic ameloblast-associated protein (ODAM) -impregnated collagen gel and in vitro mineralization assay
• in genipin gel preparation

Biochem/physiol Actions

Genipin stimulates insulin secretion in UCP2-dependent manner (Uncoupling protein 2). Genipin is a protein, collagen, gelatin, and chitosan cross-linker.

Genipin stimulates insulin secretion in UCP2-dependent manner (Uncoupling protein 2).

Features and Benefits

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves