Fortfahren mit
G3643
α1-saures Glycoprotein aus Rinderplasma
≥99%
Synonym(e):
Orosomucoid aus Rinderplasma
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 306,00 |
100 mg | Warenkorb auf Verfügbarkeit prüfen | € 828,00 |
250 mg | Warenkorb auf Verfügbarkeit prüfen | € 1.640,00 |
Über diesen Artikel
Form:
powder
Assay:
≥99%
Biological source:
bovine plasma
€ 306,00
Warenkorb auf Verfügbarkeit prüfen
Technischer Dienst
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Unterstützung erhaltenbiological source
bovine plasma
Quality Segment
assay
≥99%
form
powder
technique(s)
electrophoresis: suitable, mass spectrometry (MS): suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
bovine ... ORM1(497200)
General description
α1-Acid glycoprotein (AGP, orosomucoid) is the major plasma glycoprotein with a molecular weight of 41-43 kDa. It is responsible for possessing the complex type of glycans.
α1-Acid Glycoprotein (AGP, orosomucoid) from bovine plasma belongs to ‘lipocalins′ family which binds and transports small hydrophobic molecules. AGP is further classified into the subfamily ‘immunocalins′ which immunomodulates the inflammatory reactions. AGP is primarily produced in the liver, in few extra hepatic tissues and is present in neutrophil granules. Healthy cattle possesses 0.3 mg of AGP/ ml of concentrated serum.
Application
α1-Acid glycoprotein was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine
α1-Acid Glycoprotein (AGP) from bovine plasma has been used:
- in mass spectrometry analysis to confirm the presence of Neu5Ac and Neu5Gc distribution in human and bovine AGP respectively
- for pretreating the microvessel before perfusing the MDA-MB-231 cells for tumor adhesion studies
- in the composition of tear model
- as a reference in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)
Biochem/physiol Actions
α1-Acid Glycoprotein from bovine plasma is an acute phase protein. It has anti-inflammatory potential and its concentration increases several folds during injury. AGP increases the chemotactic activity and life span of monocytes and inhibits neutrophil degranulation. Serum AGP levels differentiates sepsis from systemic inflammatory response syndrome (SIRS).
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Dieser Artikel | |||
|---|---|---|---|
| description ≥99% | description ≥99% (agarose gel electrophoresis) | description - | description - |
| biological source bovine plasma | biological source human plasma | biological source human plasma | biological source - |
| technique(s) mass spectrometry (MS): suitable, electrophoresis: suitable | technique(s) ELISA: suitable | technique(s) - | technique(s) - |
| assay ≥99% | assay ≥99% (agarose gel electrophoresis) | assay ≥95% (SDS-PAGE) | assay ≥90% (SDS-PAGE) |
| form powder | form powder | form lyophilized | form lyophilized |
| Gene Information bovine ... ORM1(497200) | Gene Information human ... ORM1(5004) | Gene Information - | Gene Information - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
Lagerklasse
13 - Non Combustible Solids
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
Eyeshields, Gloves, type N95 (US)
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