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Merck
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Dokumente

G0668

Sigma-Aldrich

GW2974

≥98% (HPLC), solid

Synonym(e):

N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido­[3,4-d]­pyrimidine-4,6-diamine

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About This Item

Empirische Formel (Hill-System):
C23H21N7
CAS-Nummer:
202272-68-2
Molekulargewicht:
395.46
MDL-Nummer:
MFCD04974495
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24278451
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Farbe

yellow

Löslichkeit

DMSO: ≥20 mg/mL

Ersteller

GlaxoSmithKline

SMILES String

CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1

InChI

1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)

InChIKey

DYYZXRCFCVDSKD-UHFFFAOYSA-N

Angaben zum Gen

human ... EGFR(1956) , ERBB2(2064)

Biochem./physiol. Wirkung

Potent and selective dual inhibitor of EGFR (IC50 = 0.016 mM) and ErbB-2 receptor tyrosine kinase.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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S Agarwal et al.
British journal of cancer, 100(6), 941-949 (2009-02-26)
There is a pressing need to identify new drug targets and novel approaches for treatment of non-small-cell lung carcinoma (NSCLC). Members of the epidermal growth factor receptor (EGFR) and Met receptor families have been identified as important molecular targets for
Keli Kolegraff et al.
Molecular biology of the cell, 22(8), 1121-1134 (2011-02-18)
Desmocollin-2 (Dsc2) and desmoglein-2 (Dsg2) are transmembrane cell adhesion proteins of desmosomes. Reduced expression of Dsc2 has been reported in colorectal carcinomas, suggesting that Dsc2 may play a role in the development and/or progression of colorectal cancer. However, no studies
Hauke Busch et al.
Molecular systems biology, 4, 199-199 (2008-07-03)
Translation of large-scale data into a coherent model that allows one to simulate, predict and control cellular behavior is far from being resolved. Assuming that long-term cellular behavior is reflected in the gene expression kinetics, we infer a dynamic gene

Artikel

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

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