Please see the link below to for the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/613/c6645pis.pdf
C6645
Cytosin β-D-Arabinofuranosid -hydrochlorid
≥99% (HPLC), synthetic (inorganic), crystalline
Synonym(e):
Ara-C -hydrochlorid, Cytarabin -hydrochlorid
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Größe auswählen
25 MG
€ 65,60
100 MG
€ 86,60
500 MG
€ 303,00
1 G
€ 515,00
5 G
€ 1.590,00
€ 65,60
Warenkorb auf Verfügbarkeit prüfen
Über diesen Artikel
Empirische Formel (Hill-System):
C9H13N3O5 · HCl
CAS-Nummer:
Molekulargewicht:
279.68
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-713-9
MDL number:
UNSPSC Code:
12352208
Assay:
≥99% (HPLC)
Biological source:
synthetic (inorganic)
Form:
crystalline
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
2-8°C
Fortfahren mit
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenProduktname
Cytosin β-D-Arabinofuranosid -hydrochlorid, crystalline
InChI key
KCURWTAZOZXKSJ-JBMRGDGGSA-N
InChI
1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1
SMILES string
Cl[H].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
biological source
synthetic (inorganic)
assay
≥99% (HPLC)
form
crystalline
mp
197-198 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
Gene Information
Verwandte Kategorien
1 of 4
Dieser Artikel | |||
|---|---|---|---|
| biological source synthetic (inorganic) | biological source - | biological source synthetic (organic) | biological source - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 100 |
| assay ≥99% (HPLC) | assay ≥90% (HPLC) | assay ≥98% (titration) | assay ≥98% (HPLC) |
| form crystalline | form crystalline | form powder or crystals | form solid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mp 197-198 °C (lit.) | mp - | mp 67-71 °C | mp - |
Application
Cytosine β-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco′s modified eagle medium (FBS-DMEM)[1] and B27/neurobasal-A medium to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.
Biochem/physiol Actions
Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease
Lim MA, et al.
The Journal of Neuroscience, 32(3), 1123-1141 (2012)
JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models
Ploia C, et al.
Journal of Alzheimer'S Disease, 26(2), 315-329 (2011)
Vindhya Vijay et al.
Leukemia research, 84, 106180-106180 (2019-07-13)
One of the greatest challenges in treating acute myeloid leukemia (AML) is chemotherapy refractory disease. Previously, we demonstrated a novel mechanism whereby AML-induced endothelial cell (EC) activation leads to subsequent leukemia cell adherence, quiescence and chemoresistance, identifying activated ECs as
Joost J Leenders et al.
The Journal of biological chemistry, 285(35), 27449-27456 (2010-06-23)
Pathological forms of left ventricular hypertrophy (LVH) often progress to heart failure. Specific transcription factors have been identified that activate the gene program to induce pathological forms of LVH. It is likely that apart from activating transcriptional inducers of LVH
Jorge Cortes et al.
The Lancet. Oncology, 14(4), 354-362 (2013-03-05)
Tosedostat is a novel oral aminopeptidase inhibitor with clinical activity in a previous phase 1-2 study in elderly patients with relapsed or refractory acute myeloid leukaemia (AML). We aimed to compare two dosing regimens of tosedostat. In this randomised phase
Artikel
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Verwandter Inhalt
Product Information Sheet
-
Hi I need the insert of this product please. Can you send me please? the batch number is SLCD2059
1 answer-
Helpful?
-
Active Filters
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
Setzen Sie sich mit dem technischen Dienst in Verbindung