C5429

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride

Name: Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride
Brand: SIGMA
Price: 76.4 EUR

Cathepsin B substrate, powder

Synonym(e):

Z-RR-AMC

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5 MG

€ 76,40

25 MG

€ 264,00

€ 76,40

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Über diesen Artikel

Empirische Formel (Hill-System):

C₃₀H₃₉N₉O₆

CAS-Nummer:

136132-67-7

Molekulargewicht:

621.69

UNSPSC Code:

12352209

PubChem Substance ID:

24892784

NACRES:

NA.32

MDL number:

MFCD00133576

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Produktname

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,

SMILES string

Cl.CC1=CC(=O)Oc2cc(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12

InChI

1S/C30H39N9O6.ClH/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-26(41)22(9-5-13-35-28(31)32)38-27(42)23(10-6-14-36-29(33)34)39-30(43)44-17-19-7-3-2-4-8-19;/h2-4,7-8,11-12,15-16,22-23H,5-6,9-10,13-14,17H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,31,32,35)(H4,33,34,36);1H

InChI key

HLSNWWKWVKPXKI-UHFFFAOYSA-N

form

powder

impurities

~4% isopropanol

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CTSB(1508)
mouse ... CTSB(13030)
rat ... CTSB(64529)

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1 of 4

Dieser Artikel	M0938	C8571	C9521
Sigma-Aldrich C5429 Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	Sigma-Aldrich M0938 7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide	Sigma-Aldrich C8571 Cathepsin B from human liver	Sigma-Aldrich C9521 Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
form powder	form solid	form buffered aqueous solution	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −70°C	storage temp. −20°C
Gene Information human ... CTSB(1508) mouse ... CTSB(13030) rat ... CTSB(64529)	Gene Information human ... CTSD(1509), CTSE(1510) mouse ... CTSD(13033), CTSE(13034) rat ... CTSD(171293), CTSE(25424)	Gene Information human ... CTSB(1508)	Gene Information -
impurities ~4% isopropanol	impurities -	impurities -	impurities -

General description

Fluorogenic substrate for cathepsin B.

Application

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

as a cathepsin B substrate in zymography analysis of protease in feces extract.[1]
in cathepsin B activity assay.
as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Feces Derived Allergens of Tyrophagus putrescentiae Reared on Dried Dog Food and Evidence of the Strong Nutritional Interaction between the Mite and Bacillus cereus Producing Protease Bacillolysins and Exo-chitinases.

Tomas Erban et al.

Frontiers in physiology, 7, 53-53 (2016-03-05)

Tyrophagus putrescentiae (Schrank, 1781) is an emerging source of allergens in stored products and homes. Feces proteases are the major allergens of astigmatid mites (Acari: Acaridida). In addition, the mites are carriers of microorganisms and microbial adjuvant compounds that stimulate

Drought-Stressed Tomato Plants Trigger Bottom-Up Effects on the Invasive Tetranychus evansi.

Miguel G Ximénez-Embún et al.

PloS one, 11(1), e0145275-e0145275 (2016-01-07)

Climate change will bring more drought periods that will have an impact on the irrigation practices of some crops like tomato, from standard water regime to deficit irrigation. This will promote changes in plant metabolism and alter their interactions with

Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia/reperfusion injury

Cortes A L, et al.

Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(1), 102-114 (2018)

High pressure effects on the activities of cathepsins B and D of mackerel and horse mackerel muscle

Fidalgo L G

Czech Journal of Food Sciences, 7, 53-53 (2014)

Post mortem rigor development in the Egyptian goose (Alopochen aegyptiacus) breast muscle (pectoralis): factors which may affect the tenderness.

Greta Geldenhuys et al.

Journal of the science of food and agriculture, 96(1), 271-279 (2015-02-03)

Baseline research on the toughness of Egyptian goose meat is required. This study therefore investigates the post mortem pH and temperature decline (15 min-4 h 15 min post mortem) in the pectoralis muscle (breast portion) of this gamebird species. It

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Artikel

Enzymatic Assay of Cathepsin B

Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.

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Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride