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A1755

Aminophyllin

≥98%, powder

Synonym(e):

(Theophyllin)2 · Ethylendiamin, 3,7-Dihydro-1,3-dimethyl-1H-purin-2,6-dion, komplexiert mit 1,2-Ethandiamin (2:1), Theophyllin-Hemiethylendiaminkomplex

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Über diesen Artikel

Empirische Formel (Hill-System):
C7H8N4O2 · 0.5C2H8N2
CAS-Nummer:
317-34-0
Molekulargewicht:
210.21
NACRES:
NA.77
PubChem Substance ID:
24277691
UNSPSC Code:
41106305
EC Number:
206-264-5
MDL number:
MFCD00013221
Assay:
≥98%
Form:
powder
Quality level:
100

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Quality Level

100

assay

≥98%

form

powder

color

white to off-white

solubility

H2O: 50 mg/mL (solutions should be freshly prepared.), alcohol: insoluble

storage temp.

−20°C

SMILES string

NCCN.CN1C(=O)N(C)c2nc[nH]c2C1=O.CN3C(=O)N(C)c4nc[nH]c4C3=O

InChI

1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2

InChI key

FQPFAHBPWDRTLU-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

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Dieser Artikel
16531171653004PHL82668
Aminophylline ≥98%, powder

Sigma-Aldrich

A1755

Aminophylline

Theophylline melting point standard United States Pharmacopeia (USP) Reference Standard

USP

1653117

Theophylline melting point standard

Theophylline United States Pharmacopeia (USP) Reference Standard

USP

1653004

Theophylline

Theophylline phyproof® Reference Substance

PHL82668

Theophylline

assay

≥98%

assay

-

assay

-

assay

≥98.0% (HPLC)

form

powder

form

-

form

-

form

powder

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

solubility

H2O: 50 mg/mL (solutions should be freshly prepared.), alcohol: insoluble

solubility

-

solubility

-

solubility

-

color

white to off-white

color

-

color

-

color

-

Application

Aminophylline has been used:
  • as a positive control in the selective inhibitor of nuclear export, KPT-350 zebrafish dosing experiments[1]
  • as a positive control for the determination of the spasmolytic activity of C. aeruginosa extracts[2]
  • as a phosphodiesterase (PDE) inhibitor in inhibitor studies to quantify its potency to inhibit PDE4A1A and PDE3A enzyme in an assay[3]

Biochem/physiol Actions

Non-selective phosphodiesterase (PDE) inhibitor. Antiepileptic drug
Aminophylline is a methylxanthine compound containing theophylline andethylenediamine in a ratio of 2:1. It acts as a bronchodilator and is used to treat chronic lung diseases like asthma, bronchitis, or emphysema.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCT6059
MKCS2794
MKCS7148
MKCL4313
MKCJ3828

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Antiasthmatic effect of Curcuma aeruginosa extract on isolated organ of the trachea
Marliana E, et al.
F1000Research (2018)
Thieu X Phan et al.
The Journal of physiology, 598(24), 5639-5659 (2020-09-19)
The functional roles of the capsaicin receptor, TRPV1, outside of sensory nerves are unclear. We mapped TRPV1 in the mouse circulation, revealing extensive expression in the smooth muscle of resistance arterioles supplying skeletal muscle, heart and adipose tissue.  Activation of
Nicole M Bhave et al.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 14, 89-89 (2013-01-01)
Adenosine cardiovascular magnetic resonance (CMR) can accurately quantify myocardial perfusion reserve. While regadenoson is increasingly employed due to ease of use, imaging protocols have not been standardized. We sought to determine the optimal regadenoson CMR protocol for quantifying myocardial perfusion
Matt Staeben et al.
Assay and drug development technologies, 8(3), 344-355 (2010-02-18)
Screening of AMP- and GMP-producing enzymes such as phosphodiesterases (PDEs), ligases, and synthetases would be simplified by the ability to directly detect unmodified nucleoside monophosphates. To address this need, we developed polyclonal and monoclonal antibodies that recognize AMP and GMP
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Global Trade Item Number

SKUGTIN
A1755-500G04061832281360
A1755-100G04061832895635
A1755-25G04061833342961

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