95271

Vitamin K₁

BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers

• Synonym(e): 2-Methyl-3-phytyl-1,4-naphthochinon, 3-Phytylmenadion, Phyllochinon, Vitamin K₁₍₂₀₎
• Empirische Formel (Hill-System): C₃₁H₄₆O₂
• CAS-Nummer: 84-80-0
• Molekulargewicht: 450.70
• UNSPSC Code: 12352205
• NACRES: NA.79
• PubChem Substance ID: 57653664
• EC Number: 201-564-2
• Beilstein/REAXYS Number: 2568816
• MDL number: MFCD00214063
• eCl@ss: 34058015

Eigenschaften

• InChI key: MBWXNTAXLNYFJB-NKFFZRIASA-N
• InChI: 1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
• SMILES string: O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O
• biological source: synthetic
• product line: BioXtra
• assay: ≥99.0% (sum of isomers, HPLC)
• form: viscous liquid
• impurities: ≤20% cis-isomer
• ign. residue: ≤0.1% (as SO₄)
• color: light green-yellow to dark green-yellow, light yellow to dark yellow
• refractive index: n20/D 1.527 (lit.)
• mp: −20 °C (lit.)
• density: 0.984 g/mL at 25 °C (lit.)
• cation traces: Al: ≤5 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤100 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤10 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg
• storage temp.: 2-8°C
• Quality Level: 200

Beschreibung

General description

Vitamin K₁, also known as phylloquinone, consists of naphthalenoid and phytyl groups.[1] Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source.[2] It is a fat-soluble vitamin.[3]

Application

<ul>
<li><strong>Nutritional strategies for musculoskeletal health:</strong> Nutritional strategies, including Vitamin K1, optimize musculoskeletal health for fall and fracture prevention beyond traditional nutrients like calcium and vitamin D (Webster et al., 2023 doi:10.1016/j.bonr.2023.101684).</li>
<li><strong>Role in coagulation and bone health:</strong> A comprehensive review highlights Vitamin K1′s role in reducing cardiovascular risks and details its biochemical interactions affecting coagulation and bone health (Zhao et al., 2024 doi:10.1017/jns.2023.106).</li>
</ul>

Biochem/physiol Actions

Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor.

Vitamin K₁ plays a role as a cofactor in the synthesis of γ- carboxy glutamate (Gla), formation of coagulation factors II (prothrombin), VII, IX and X.[4]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Review: Vitamin K and γ-carboxyglutamate biosynthesis[5]; Metabolic functions and mechanism of action[6]

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves