Product H5534 is tested and recommended for cell culture applications. Product 56250 has not been tested for the suitability of cell culture and would need to be validated by the end-user.
Fortfahren mit
56250
Trans-4-Hydroxy-L -Prolin
≥99.0% (NT), BioXtra
Synonym(e):
(2S,4R)-4-Hydroxy-pyrrolidin-2-carbonsäure, Hyp
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Über diesen Artikel
Empirische Formel (Hill-System):
C5H9NO3
CAS-Nummer:
Molekulargewicht:
131.13
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-091-9
MDL number:
Beilstein/REAXYS Number:
81441
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Technischer Dienst
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Unterstützung erhaltenProduktname
Trans-4-Hydroxy-
product line
BioXtra
Quality Segment
assay
≥99.0% (NT)
form
solid
optical activity
[α]20/D −76.0±1.5°, c = 5% in H2O
impurities
≤0.3% foreign amino acids
ign. residue
≤0.1% (as SO4)
loss
≤0.1% loss on drying, 110 °C
color
colorless to white
mp
273 °C (dec.) (lit.)
anion traces
chloride (Cl-): ≤100 mg/kg, sulfate (SO42-): ≤100 mg/kg
cation traces
Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, NH4+: ≤100 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg
application(s)
peptide synthesis
SMILES string
O[C@H]1CN[C@@H](C1)C(O)=O
InChI
1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI key
PMMYEEVYMWASQN-DMTCNVIQSA-N
Biochem/physiol Actions
Trans-4-Hydroxy-L-proline is used as a starting material in the synthesis of (-)-secrinine; the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of prolinol ring and in asymmetric synthesis of the ABC-ring system of the antitumor antibiotic MPC1001.
Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.
Other Notes
Enzymes and intermediates of hydroxyproline degradation
natürliche Komponente von tierischen Proteinen wie Collagen und Elastin
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Dieser Artikel | |||
|---|---|---|---|
| description BioXtra, ≥99.0% (NT) | description BioReagent, suitable for cell culture, ≥98.5% | description ≥99% | description Pharmaceutical Secondary Standard; Certified Reference Material |
| form solid | form crystalline | form crystalline powder | form - |
| assay ≥99.0% (NT) | assay ≥98.5% | assay ≥99% | assay - |
| product line BioXtra | product line BioReagent | product line - | product line - |
| color colorless to white | color colorless | color white to off-white | color - |
| mp 273 °C (dec.) (lit.) | mp 273 °C (dec.) (lit.) | mp 273 °C (dec.) (lit.) | mp 273 °C (dec.) (lit.) |
| impurities ≤0.3% foreign amino acids | impurities endotoxin, tested | impurities - | impurities - |
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we need to use this component for cell culture. Is 56250 suitable (BioXtra, ≥99.0% (NT)) or we need to order the H5534 (BioReagent, suitable for cell culture, ≥98.5%)
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