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Merck

462R-1

Sigma-Aldrich

SF-1 (EP434) Rabbit Monoclonal Primary Antibody

Synonym(e):

Steroidogenic Factor-1

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About This Item

UNSPSC-Code:
12352203
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Biologische Quelle

rabbit

Qualitätsniveau

100
500

Konjugat

unconjugated

Antikörperform

culture supernatant

Antikörper-Produkttyp

primary antibodies

Klon

EP434, monoclonal

Beschreibung

For In Vitro Diagnostic Use in Select Regions

Form

buffered aqueous solution

Speziesreaktivität

human

Verpackung

vial of 0.1 mL concentrate (462R-14)
vial of 0.1 mL concentrate Research Use Only (462R-14-RUO)
vial of 0.5 mL concentrate (462R-15)
vial of 1.0 mL concentrate (462R-16)
vial of 1.0 mL concentrate Research Use Only (462R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (462R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (462R-17)
vial of 7.0 mL pre-dilute ready-to-use (462R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (462R-18-RUO)

Hersteller/Markenname

Cell Marque®

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

Isotyp

IgG

Kontrolle

adrenocortical carcionma, granulosa cell tumor, testis

Versandbedingung

wet ice

Lagertemp.

2-8°C

Visualisierung

nuclear

Angaben zum Gen

human ... SF1(7536)

Allgemeine Beschreibung

As both a nuclear receptor and nuclear transcription factor, Steroidogenic factor-1 (SF-1) serves as an important modulator of steroidogenesis.[1][2] It has been demonstrated that SF-1 serves as a “master regulator” in varying facets of development and function in both reproductive and adrenal tissues.[1] Immunohistochemical detection of SF-1 in testicular tissue may provide value for distinguishing sex-cord stromal tumors, including Leydig cell, Sertoli cell and granulosa cell neoplasms, from other tumors.[2][3] In addition, SF-1 detection may have utility in distinguishing primary adrenal cortical lesions from their histologic mimics such as renal clear cell carcinoma.[4]

Qualität


IVD

IVD

IVD

RUO

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Angaben zur Herstellung

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Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: [email protected]

Rechtliche Hinweise

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Ankur R Sangoi et al.
Applied immunohistochemistry & molecular morphology : AIMM, 21(4), 318-321 (2012-11-21)
Differentiating testicular germ cell tumors from sex-cord stromal tumors can be difficult in certain cases because of overlapping morphologic features and/or an absence of clinically apparent hormonal symptoms. Immunohistochemistry may be needed as an ancillary diagnostic tool in this differential
Chengquan Zhao et al.
The American journal of surgical pathology, 33(3), 354-366 (2008-11-27)
Different immunohistochemical sex cord-stromal markers have been previously studied in various types of ovarian sex cord-stromal tumors; however, the sensitivity for sex cord-stromal lineage may vary between markers, and some markers may not be as sensitive in some types of
Ranna El-Khairi et al.
Seminars in reproductive medicine, 30(5), 374-381 (2012-10-10)
Steroidogenic factor-1 (SF-1) (Ad4BP, NR5A1) is a nuclear receptor that plays a key role in adrenal and reproductive development and function. Deletion of the gene encoding Sf-1 (Nr5a1) in mice results in severe developmental defects of the adrenal gland and
Ankur R Sangoi et al.
The American journal of surgical pathology, 35(5), 678-686 (2011-04-15)
The diagnosis of metastatic clear cell renal cell carcinoma (CC-RCC) can be difficult because of its morphologic heterogeneity and the increasing use of small image-guided biopsies that yield scant diagnostic material. This is further complicated by the degree of morphologic

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