46121

Resorufinethylether

suitable for fluorescence, ≥95% (UV)

• Synonym(e): 7-Ethoxy-3H-phenoxazin-3-on, Ethoxyresorufin, O⁷-Ethylresorufin
• Empirische Formel (Hill-System): C₁₄H₁₁NO₃
• CAS-Nummer: 5725-91-7
• Molekulargewicht: 241.24
• UNSPSC Code: 12161501
• NACRES: NA.32
• PubChem Substance ID: 329757074
• MDL number: MFCD00037661
• Beilstein/REAXYS Number: 225973

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (UV)
• form: solid
• mp: 223-225 °C (lit.)
• solubility: DMF: soluble, DMSO: soluble, alcohols: soluble
• fluorescence: λ_ex 464 nm; λ_em 540 nm in methanol(lit.), λ_ex 571 nm; λ_em 585 nm in dealkylase(lit.)
• suitability: suitable for fluorescence
• storage temp.: 2-8°C
• SMILES string: CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F
• InChI: 1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3
• InChI key: ZOSYTBPPLWBBKM-UHFFFAOYSA-N

Beschreibung

Application

7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450[1][2]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)