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Merck

42867

Dextransulfat Natriumsalz

Mr ~40,000

Synonym(e):

DSS-Dextransulfat-Natrium

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5 G

€ 117,00

25 G

€ 445,00

100 G

€ 1.340,00

€ 117,00


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Über diesen Artikel

NACRES:
NA.25
UNSPSC Code:
12352201

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Unterstützung erhalten

form

powder

mol wt

Mr ~40,000

Quality Level

technique(s)

tissue culture: suitable

loss

≤10% loss on drying

color

white to off-white

useful pH range

6.0-8 (10 g/L)

mp

(Decomposes on heating.)

solubility

water: soluble

suitability

suitable for component for culture media

storage temp.

room temp

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Dieser Artikel
512277502767578
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

solubility

water: soluble

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

color

white to off-white

color

white

color

colorless

color

-

mp

(Decomposes on heating.)

mp

-

mp

-

mp

-

General description

Dextran ist ein Polymer von Anhydroglucose. Es besteht aus ca. 95 % alpha-D-(166)-Verbindungen. Die restlichen (163) Verbindungen tragen zur Verzweigung des Dextrans bei.

Application

Dextransulfat wird regelmäßig verwendet für die selektive Fällung von Lipoproteinen, Sondenhybridisierung membranimmobilisierter DNA, Freisetzung von DNA aus DNA-Histonkomplexen und Hemmung der RNA-Bindung an Ribosomen.

Biochem/physiol Actions

Die Behandlung mit Dextransulfat-Natrium löst bei Mäusen und Ratten die Entstehung von Colitis aus, indem es im Kolon an Fettsäuren mittlerer Kettenlänge bindet und eine Entzündung induziert. [1]

Other Notes

Für einen umfassenden Überblick über unser vielfältiges Angebot an Dextranen für Ihre Forschung empfehlen wir Ihnen den Besuch unserer Seite zur Kategorie Kohlenhydrate.

Lagerklasse

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Hamed Laroui et al.
PloS one, 7(3), e32084-e32084 (2012-03-20)
Inflammatory bowel diseases (IBDs), primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model. DSS induces in vivo but not in vitro intestinal
Andrey V Markov et al.
Molecules (Basel, Switzerland), 25(10) (2020-05-28)
Semi-synthetic triterpenoids, bearing cyano enone functionality in ring A, are considered to be novel promising therapeutic agents with complex inhibitory effects on tissue damage, inflammation and tumor growth. Previously, we showed that the cyano enone-containing 18βH-glycyrrhetinic acid derivative soloxolone methyl
Li Cao et al.
International immunopharmacology, 72, 264-274 (2019-04-21)
Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To
N Facchinello et al.
Scientific reports, 7(1), 4371-4371 (2017-07-01)
Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and compared its phenotypes with wild type and a zebrafish
Yueqin He et al.
Scientific reports, 10(1), 10180-10180 (2020-06-25)
CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental colitis. The underlying mechanism, however, remains incompletely understood. In this study, we characterized the role of CD47 in modulating homeostasis of gastrointestinal tract. We found that CD47 expression in

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Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Does DDS (Dextran Sodium Sulfate) come in a USP grade for a animal studies?

    1 answer
    1. Unfortunately, there is no pharmaceutical grade Dextran Sodium Sulfate available at this time. This product is not tested for use in animal models. It would be up to the researcher to determine suitability.

      Helpful?

  4. Hello! I want to know if you can autoclave water with 4% of dextran sulfate sodium (DSS) without decomposing the DSS.

    1 answer
    1. The solubility of dextran sulfates is tested at 100 mg/mL in water. Clear solutions are obtained. Buffered aqueous dextran sulfate solutions can be sterilized by autoclaving at 110-115 °C for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. Dextran sulfate has a higher affinity for calcium ions than for sodium ions. The calcium salt of dextran sulfate is insoluble. The free acid (hydrogen) form of dextran sulfate is extremely acidic and autohydrolyzes rapidly in solution and as a powder.

      More information can be found here: https://www.sigmaaldrich.com/technical-documents/protocol/protein-biology/protein-pulldown/dextran-sulfate

      Helpful?

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