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312M-1

Sigma-Aldrich

PAX-5 (24) Mouse Monoclonal Antibody

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100
500

Konjugat

unconjugated

Antikörperform

culture supernatant

Antikörper-Produkttyp

primary antibodies

Klon

24, monoclonal

Beschreibung

For In Vitro Diagnostic Use in Select Regions (See Chart)

Form

buffered aqueous solution

Speziesreaktivität

human

Verpackung

bottle of 1.0 mL predilute (312M-17)
bottle of 7.0 mL predilute (312M-18)

Hersteller/Markenname

Cell Marque™

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotyp

IgG1

Kontrolle

tonsil

Versandbedingung

wet ice

Lagertemp.

2-8°C

Visualisierung

nuclear

Angaben zum Gen

human ... PAX5(5079)

Allgemeine Beschreibung

PAX-5 encodes for B-cell-specific activator protein (BSAP), a marker for B-cells, including B-lymphoblastic neoplasms and maturation stage. It is found in most cases of mature and precursor B-cell non-Hodgkin lymphomas/leukemias. In approximately 97% of cases of classic Hodgkin lymphoma, Reed-Sternberg cells express PAX-5. PAX-5 is not detected in multiple myeloma and solitary plasmacytoma, making it useful for such differentiation. Diffuse large B-cell lymphomas do express PAX-5, save for those with terminal B-cell differentiation. T-cell neoplasms do not stain with anti-PAX-5. There is a strong association with CD20 expression.

Qualität


IVD
IVD
IVD
RUO

Verlinkung

PAX-5 Positive Control Slides, Product No. 312S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Angaben zur Herstellung

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Rechtliche Hinweise

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Brunangelo Falini et al.
Blood, 99(2), 409-426 (2002-01-10)
Acquired chromosomal anomalies (most commonly translocations) in lymphoma and leukemia usually result in either activation of a quiescent gene (by means of immunoglobulin or T-cell-receptor promotors) and expression of an intact protein product, or creation of a fusion gene encoding
Ines Schwering et al.
Blood, 101(4), 1505-1512 (2002-10-24)
Hodgkin and Reed-Sternberg (HRS) cells represent the malignant cells in classical Hodgkin lymphoma (HL). Because their immunophenotype cannot be attributed to any normal cell of the hematopoietic lineage, the origin of HRS cells has been controversially discussed, but molecular studies
Emina Torlakovic et al.
The American journal of surgical pathology, 26(10), 1343-1350 (2002-10-03)
Whereas L26 (anti-CD20) is well established as a B-cell marker of high specificity for use in paraffin-embedded tissues and JCB117 (anti-CD79a) is increasingly used, a comparable additional pan-B-cell antibody has hitherto not yet been identified. Here we have studied the
Klaus Willenbrock et al.
Laboratory investigation; a journal of technical methods and pathology, 82(9), 1103-1109 (2002-09-10)
The atypical cells of CD30(+) cutaneous lymphoproliferative disorders (CD30CLD) are commonly of T-cell origin and frequently have a similar morphology as Hodgkin or Reed-Sternberg cells of Hodgkin's lymphoma (HL). HL is one of the tumors associated with CD30CLD. Although most

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